{"id":4397,"date":"2025-02-18T22:21:34","date_gmt":"2025-02-18T14:21:34","guid":{"rendered":"https:\/\/www.cib.cc\/?page_id=4397"},"modified":"2025-09-28T10:29:14","modified_gmt":"2025-09-28T02:29:14","slug":"%e5%b8%95%e9%87%91%e6%a3%ae%e7%97%87%e6%a8%a1%e5%9e%8b","status":"publish","type":"page","link":"https:\/\/www.cib.cc\/?page_id=4397","title":{"rendered":"\u5e15\u91d1\u68ee\u75c7\u6a21\u578b"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4397\" class=\"elementor elementor-4397\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4865314 e-flex e-con-boxed e-con e-parent\" data-id=\"4865314\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8b22ddd e-con-full e-flex e-con e-child\" data-id=\"8b22ddd\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-255945d elementor-widget elementor-widget-hfe-breadcrumbs-widget\" data-id=\"255945d\" data-element_type=\"widget\" data-widget_type=\"hfe-breadcrumbs-widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"hfe-breadcrumbs hfe-breadcrumbs-show-home\"><li class=\"hfe-breadcrumbs-item hfe-breadcrumbs-first\"><span class=\"hfe-breadcrumbs-home-icon\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-home\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M280.37 148.26L96 300.11V464a16 16 0 0 0 16 16l112.06-.29a16 16 0 0 0 15.92-16V368a16 16 0 0 1 16-16h64a16 16 0 0 1 16 16v95.64a16 16 0 0 0 16 16.05L464 480a16 16 0 0 0 16-16V300L295.67 148.26a12.19 12.19 0 0 0-15.3 0zM571.6 251.47L488 182.56V44.05a12 12 0 0 0-12-12h-56a12 12 0 0 0-12 12v72.61L318.47 43a48 48 0 0 0-61 0L4.34 251.47a12 12 0 0 0-1.6 16.9l25.5 31A12 12 0 0 0 45.15 301l235.22-193.74a12.19 12.19 0 0 1 15.3 0L530.9 301a12 12 0 0 0 16.9-1.6l25.5-31a12 12 0 0 0-1.7-16.93z\"><\/path><\/svg><\/span><a href=\"https:\/\/www.cib.cc\"><span class=\"hfe-breadcrumbs-text\">\u9996\u9875<\/span><\/a><\/li><\/ul>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b1765c0 e-flex e-con-boxed e-con e-child\" data-id=\"b1765c0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8037bdb elementor-widget__width-initial fix-side elementor-widget elementor-widget-shortcode\" data-id=\"8037bdb\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5658\" class=\"elementor elementor-5658\">\n\t\t\t\t<div class=\"elementor-element elementor-element-34b33e9 e-flex e-con-boxed e-con e-parent\" data-id=\"34b33e9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f08a7c elementor-widget elementor-widget-html\" data-id=\"6f08a7c\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<script>\ndocument.addEventListener(\"DOMContentLoaded\", function() {\n    var currentUrl = window.location.href; \/\/ \u83b7\u53d6\u5f53\u524d\u9875\u9762\u7684\u8def\u5f84\n    var navLinks = document.querySelectorAll('.cib-side-bar a'); \/\/ \u83b7\u53d6\u6240\u6709\u5bfc\u822a\u94fe\u63a5\n    navLinks.forEach(function(link) {\n        if (link.href === currentUrl) { \/\/ \u5982\u679c\u94fe\u63a5\u7684href\u5305\u542b\u5f53\u524d\u8def\u5f84\n            \/\/link.style.backgroundColor = 'white'; \/\/ \u8bbe\u7f6e\u80cc\u666f\u8272\u4e3a\u767d\u8272\n            link.style.color = '#004C97';\n            var parent = link.parentElement;\n            parent.style.backgroundColor = 'white';\n        } \n    });\n});\n<\/script>\n\n<style>\n    .cib-side-bar {\n        text-indent: 20px; \/* \u589e\u52a0\u6587\u672c\u7f29\u8fdb *\/\n    }\n    #cib-side-bar-hd, #cib-side-bar-ad, #cib-side-bar-pd, #cib-side-bar-lqt, #cib-side-bar-fh {\n    text-indent: 40px; \/* \u589e\u52a0\u6587\u672c\u7f29\u8fdb *\/\n    }\n    .cib-side-bar a{\n        color:#38454A;\n    }\n    .cib-side-bar a:hover{\n        font-weight:bold;\n        color:#004397;\n<\/style>\n\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9e84b25 e-con-full e-flex e-con e-child\" data-id=\"9e84b25\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a0c99f1 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"a0c99f1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4344\">iPSCell<sup>\u24c7<\/sup>\u5165\u95e8\u7248 iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46cb84f elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"46cb84f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4348\">iPSCell<sup>\u24c7<\/sup>\u5206\u5316\u9a8c\u8bc1 iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc3ffeb elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"bc3ffeb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4369\">iPSCell<sup>\u24c7<\/sup>\u62a5\u544a\u57fa\u56e0 iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec461c2 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"ec461c2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4375\">iPSCell<sup>\u24c7<\/sup>\u75be\u75c5\u6a21\u578b iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc0263d elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"bc0263d\" data-element_type=\"widget\" id=\"cib-side-bar-pd\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4397\">\u5e15\u91d1\u68ee\u75c7<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb1657d elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"bb1657d\" data-element_type=\"widget\" id=\"cib-side-bar-ad\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4627\">\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-53e6ef3 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"53e6ef3\" data-element_type=\"widget\" id=\"cib-side-bar-lqt\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4628\">\u9057\u4f20\u6027\u957f QT \u7efc\u5408\u75c7<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57302ad elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"57302ad\" data-element_type=\"widget\" id=\"cib-side-bar-fh\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4626\">\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a9afe9 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"4a9afe9\" data-element_type=\"widget\" id=\"cib-side-bar-hd\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4629\">\u809d\u8c46\u72b6\u6838\u53d8\u6027<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-124e3f4 e-con-full e-flex e-con e-child\" data-id=\"124e3f4\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d433c3c e-con-full e-flex e-con e-child\" data-id=\"d433c3c\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-124fe8f e-con-full e-flex e-con e-child\" data-id=\"124fe8f\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-57e4de0 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"57e4de0\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u5e15\u91d1\u68ee\u75c7\uff08Parkinson\u2019s disease\uff09\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u4e3b\u8981\u7279\u70b9\u4e3a\u9759\u6b62\u6027\u9707\u98a4\u3001\u8fd0\u52a8\u8fdf\u7f13\u3001\u808c\u5f3a\u76f4\u548c\u59ff\u52bf\u5e73\u8861\u969c\u788d\u7b49\u8fd0\u52a8\u75c7\u72b6\uff0c\u4ee5\u53ca\u4fbf\u79d8\u3001\u55c5\u89c9\u969c\u788d\u3001\u7761\u7720\u969c\u788d\u7b49\u975e\u8fd0\u52a8\u75c7\u72b6\u3002\u8be5\u75c5\u591a\u53d1\u4e8e60\u5c81\u4ee5\u4e0a\u4eba\u7fa4\uff0c\u7537\u6027\u60a3\u75c5\u7387\u7565\u9ad8\u4e8e\u5973\u6027\uff0c\u5168\u7403\u60a3\u75c5\u7387\u7ea6\u4e3a1.51\uff05\u3002\u53d1\u75c5\u673a\u7406\u4e3b\u8981\u4e0e\u9ed1\u8d28\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u53d8\u6027\u6b7b\u4ea1\u6709\u5173\uff0c\u53ef\u80fd\u7531\u9057\u4f20\u56e0\u7d20\u3001\u73af\u5883\u56e0\u7d20\u3001\u795e\u7ecf\u7cfb\u7edf\u8001\u5316\u7b49\u591a\u79cd\u56e0\u7d20\u5171\u540c\u4f5c\u7528\u5bfc\u81f4\u3002<\/p><p>PD \u7684\u4e3b\u8981\u75c5\u7406\u7279\u5f81\u662f\u5728\u9ed1\u8d28\u7eb9\u72b6\u4f53\u7cfb\u7edf\u7a81\u89e6\u6838\u86cb\u767d\u5f62\u6210\u8def\u6613\u5c0f\u4f53\uff08Lewy body\uff09\u5e76\u4f34\u968f\u591a\u5df4\u80fa\u795e\u7ecf\u5143\u6e10\u8fdb\u6027\u4e22\u5931\u3002\u90e8\u5206\u60a3\u8005\u5b58\u5728\u9057\u4f20\u503e\u5411\uff0c\u7ea610%\u60a3\u8005\u5b58\u5728\u5bb6\u65cf\u53f2\u3002\u76ee\u524d\u5df2\u786e\u5b9a\u51e0\u4e2a\u81f4\u75c5\u57fa\u56e0\uff0c\u5982 PARK2\uff08\u4e5f\u79f0 PRKN\uff09\u3001PINK1\uff0cPARK7 \uff08\u4e5f\u79f0 DJ-1\uff09\uff0cLRRK2\uff0cSNCA \u7b49\u3002\u90e8\u5206\u57fa\u56e0\u4e3a\u5e38\u67d3\u8272\u4f53\u663e\u6027\uff0c\u800c\u53e6\u4e00\u90e8\u5206\u4e3a\u5e38\u67d3\u8272\u4f53\u9690\u6027\u9057\u4f20\u3002\u9057\u4f20\u6027 PD \u53d1\u75c5\u5e74\u9f84\u66f4\u65e9\uff0c\u6bd4\u5982\u9752\u5e74\u578b PD (young-onset Parkinson\u2019s disease\uff1bYOPD) \u53d1\u75c5\u5e74\u9f84\u572821-50\u5c81\u4e4b\u95f4\u3002<\/p><p>\u5728 iPSC \u6280\u672f\u51fa\u73b0\u4e4b\u524d\uff0cPD \u7684\u5e38\u89c1\u4f53\u5916\u6a21\u578b\u4e3b\u8981\u4e3a SH-SY5Y \u4eba\u795e\u7ecf\u6bcd\u7ec6\u80de\u7624\u7ec6\u80de\u7cfb\u7ecf\u795e\u7ecf\u6bd2\u5242\u5904\u7406\uff0c\u6216\u4f7f\u7528\u6765\u6e90\u4e8e\u5927\u9f20\u80be\u4e0a\u817a\u55dc\u94ec\u7ec6\u80de\u7624\u7684\u539f\u4ee3\u7ec6\u80de\u7cfbPC12 \u7ecf\u5206\u5316\u5904\u7406\u83b7\u5f97\uff0c\u4f46\u8fd9\u4e9b\u6a21\u578b\u65e0\u6cd5\u53cd\u5e94 PD \u75c5\u4eba\u7684\u75c5\u7406\u72b6\u6001\u3002\u76ee\u524d\uff0c\u501f\u52a9 iPSC \u6280\u672f\uff0c\u643a\u5e26\u6613\u611f\u57fa\u56e0\u7684 PD \u60a3\u8005\u6765\u6e90\u7684 iPSCs \u6a21\u578b\uff0c\u4ee5\u53ca\u5c06 PD \u7684\u5404\u79cd\u7a81\u53d8\uff08\u5982 SNCA1\u3001 LRRK2\u3001 UCH-L1\u3001 Parkin\u3001 PINK1\u3001 PARK7\u3001ATP13A2 \u7b49\uff09\u5f15\u5165\u5bf9\u7167 iPSCs\uff0c\u6216\u5bf9 iPSC \u8bf1\u5bfc\u7684\u795e\u7ecf\u5143\u7528 Rotenone\u3001MPP+\u3001MPTP\u30016-OHDA \u7b49\u5904\u7406\u83b7\u5f97\u7684 PD \u6a21\u578b\u8fdb\u884c\u673a\u7406\u548c\u836f\u7269\u7b5b\u9009\u7814\u7a76\u3002<\/p><p>\u4e09\u542f\u751f\u7269\u76ee\u524d\u5df2\u5efa\u7acb\u4e86\u57fa\u4e8e\u5065\u5eb7 iPSC \u6765\u6e90\u795e\u7ecf\u5143\u7ecf Rotenone \u8bf1\u5bfc\u7684 PD \u6a21\u578b\u548c\u57fa\u4e8eYOPD iPSC \u6765\u6e90\u795e\u7ecf\u5143\u7684 PD \u6a21\u578b\u7528\u4e8e PD \u836f\u7269\u7b5b\u9009\u53ca\u6709\u6548\u6027\u9a8c\u8bc1\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4294c1b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4294c1b\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5daa792 e-con-full e-flex e-con e-child\" data-id=\"5daa792\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7c10d9c elementor-widget elementor-widget-heading\" data-id=\"7c10d9c\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Isogenic \u5e15\u91d1\u68ee\u75c7\u6a21\u578b\uff08Parkinson disease\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-928e336 elementor-widget__width-inherit cib-ta-con elementor-widget elementor-widget-shortcode\" data-id=\"928e336\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n<table id=\"tablepress-61\" class=\"tablepress tablepress-id-61\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">\u8d27\u53f7<\/th><th class=\"column-2\">\u4eb2\u672c\u7ec6\u80de(\u8d27\u53f7)<\/th><th class=\"column-3\">\u57fa\u56e0\u4fe1\u606f<\/th><th class=\"column-4\">\u57fa\u56e0\u578b<\/th><th class=\"column-5\">\u89c4\u683c<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">iPSM0033<\/td><td class=\"column-2\"><a href=\"https:\/\/www.cib.cc\/?page_id=4348\" target=\"_blank\">iPSN0003<\/a><\/td><td class=\"column-3\">Knockout the Park2 gene<\/td><td class=\"column-4\">Park2 -\/-<\/td><td class=\"column-5\">\uff5e1E6<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">iPSM0035<\/td><td class=\"column-2\"><a href=\"https:\/\/www.cib.cc\/?page_id=4348\" target=\"_blank\">iPSN0003<\/a><\/td><td class=\"column-3\">Knockout the Park7 gene<\/td><td class=\"column-4\">Park7 -\/-<\/td><td class=\"column-5\">\uff5e1E6<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">iPSM0037<\/td><td class=\"column-2\"><a href=\"https:\/\/www.cib.cc\/?page_id=4348\" target=\"_blank\">iPSN0003<\/a><\/td><td class=\"column-3\">Knockout the Pink1 gene<\/td><td class=\"column-4\">Pink1 -\/-<\/td><td class=\"column-5\">\uff5e1E6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-61 from cache --><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-31cf61e e-con-full e-flex e-con e-child\" data-id=\"31cf61e\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0841a1d elementor-widget elementor-widget-heading\" data-id=\"0841a1d\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u9752\u5e74\u578b\u5e15\u91d1\u68ee\u6a21\u578b\uff08Young-onset Parkinson\u2019s disease\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c0e21bf elementor-widget__width-inherit cib-ta-con elementor-widget elementor-widget-shortcode\" data-id=\"c0e21bf\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n<table id=\"tablepress-62\" class=\"tablepress tablepress-id-62\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">\u8d27\u53f7<\/th><th class=\"column-2\">\u57fa\u56e0\u4fe1\u606f<\/th><th class=\"column-3\">\u7ec4\u7ec7\u6765\u6e90<\/th><th class=\"column-4\">\u91cd\u7f16\u7a0b\u5de5\u5177<\/th><th class=\"column-5\">\u4f9b\u4f53\u4eba\u79cd<\/th><th class=\"column-6\">\u4f9b\u4f53\u5e74\u9f84<\/th><th class=\"column-7\">\u4f9b\u4f53\u6027\u522b<\/th><th class=\"column-8\">\u89c4\u683c<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">iPSD0036<\/td><td class=\"column-2\">\u6742\u5408\u578b Cys154Phe and Cys337Tyr in PRKN<br> \u6742\u5408\u578b Pro143Ala in HTRA2<\/td><td class=\"column-3\">PBMC<\/td><td class=\"column-4\">Sendai virus<\/td><td class=\"column-5\">Asian<\/td><td class=\"column-6\">30<\/td><td class=\"column-7\">\u5973<\/td><td class=\"column-8\">\uff5e1E6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-62 from cache --><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5185a66 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"5185a66\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1612\" height=\"1125\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/YOPDiPSC\u53ca\u5176\u5206\u5316\u800c\u6765\u7684\u795e\u7ecf\u5143.png\" class=\"attachment-full size-full wp-image-7122\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">YOPD iPSC \u53ca\u5176\u5206\u5316\u800c\u6765\u7684\u795e\u7ecf\u5143<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ab1a1e8 e-con-full e-flex e-con e-child\" data-id=\"ab1a1e8\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e46e31b elementor-widget elementor-widget-heading\" data-id=\"e46e31b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u9002\u7528\u4e8e\u5e15\u91d1\u68ee\u836f\u7269\u7b5b\u9009\u7684\u8bd5\u5242\u76d2<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-885b218 cib-ta-con elementor-widget elementor-widget-shortcode\" data-id=\"885b218\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n<table id=\"tablepress-60\" class=\"tablepress tablepress-id-60\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">\u8d27\u53f7<\/th><th class=\"column-2\">\u4ea7\u54c1\u540d\u79f0<\/th><th class=\"column-3\">\u4ea7\u54c1\u63cf\u8ff0<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">iNM-002<\/td><td class=\"column-2\">\u8bf1\u5bfc\u578b\u5e15\u91d1\u68ee\u75be\u75c5\u6a21\u578b\u836f\u7269\u7b5b\u9009\u8bd5\u5242\u76d2<\/td><td class=\"column-3\">\u6b63\u5e38\u4ebaiPSC\u8bf1\u5bfc\u7684\u795e\u7ecf\u7ec6\u80de\uff0c\u7ecfRotenone\u5904\u7406\u83b7\u5f97\u7684\u5e15\u91d1\u68ee\u75be\u75c5\u6a21\u578b<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">iNM-036-Y<\/td><td class=\"column-2\">\u9752\u5e74\u578b\u5e15\u91d1\u68ee\u75be\u75c5\u6a21\u578b\u836f\u7269\u7b5b\u9009\u8bd5\u5242\u76d2<\/td><td class=\"column-3\">YOPD\u75c5\u4ebaiPSC\u8bf1\u5bfc\u7684\u795e\u7ecf\u7ec6\u80de\uff0c\u83b7\u5f97\u7684\u5e15\u91d1\u68ee\u75be\u75c5\u6a21\u578b <\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-60 from cache --><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0f5fe11 e-con-full e-flex e-con e-child\" data-id=\"0f5fe11\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-d1b4719 e-con-full e-flex e-con e-child\" data-id=\"d1b4719\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3614aa9 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"3614aa9\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-da4c288 elementor-widget elementor-widget-heading\" data-id=\"da4c288\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u836f\u7b5b\u6570\u636e<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b73b18b elementor-widget elementor-widget-text-editor\" data-id=\"b73b18b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>1. \u836f\u7b5b\u8bd5\u5242\u76d2\uff1a iNM-036-Y \uff0c\u7ec6\u80de\uff1aiPSD0036 neurons <\/strong><br \/>\u5c0f\u5206\u5b50\u5316\u5408\u7269\u5728 YOPD \u75be\u75c5\u6a21\u578b\u4e2d\u5bf9\u7ec6\u80de\u6d3b\u6027\u7684\u63d0\u5347, \u5176\u4e2d m24 C3 \u548c C4\u3001m113 C1 \u548c C2 \u5bf9\u9752\u5e74\u578b\u5e15\u91d1\u68ee\u7684\u7ec6\u80de\u6a21\u578b\u5177\u6709\u4fdd\u62a4\u4f5c\u7528<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-52e2b87 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"52e2b87\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"1099\" height=\"510\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u5c0f\u5206\u5b50\u5316\u5408\u7269\u5728YOPD\u75be\u75c5\u6a21\u578b\u4e2d\u5bf9\u7ec6\u80de\u6d3b\u6027\u7684\u63d0\u5347.png\" class=\"attachment-full size-full wp-image-7634\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-938b97d elementor-widget elementor-widget-text-editor\" data-id=\"938b97d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>2. \u836f\u7b5b\u8bd5\u5242\u76d2\uff1a iNM-002\uff0c\u7ec6\u80de\uff1aiPSN0003 neurons<\/strong><br \/>\u9633\u6027\u5c0f\u5206\u5b50\u836f\u7269\u5bf9 PD \u6a21\u578b\uff08 Rotenone\u6740\u4f24\u9020\u6a21\uff09\u795e\u7ecf\u5143\u7684\u6539\u5584\uff0c\u5176\u4e2d m0\u3001TCM21 \u5bf9 Rotenone \u5904\u7406\u7684\u795e\u7ecf\u5143\u6709\u660e\u663e\u7684\u4fdd\u62a4\u4f5c\u7528<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f21f51 elementor-widget__width-initial elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"1f21f51\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"860\" height=\"586\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u9633\u6027\u5c0f\u5206\u5b50\u836f\u7269\u5bf9\u7ecfPD\u6a21\u578b\uff08-Rotenone\u6740\u4f24\u9020\u6a21\uff09\u795e\u7ecf\u5143\u7684\u6539\u5584-1.png\" class=\"attachment-full size-full wp-image-7637\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">\n<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cca4695 e-con-full e-flex e-con e-child\" data-id=\"cca4695\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e101a63 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e101a63\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f249f7b elementor-widget elementor-widget-heading\" data-id=\"f249f7b\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u53c2\u8003\u6587\u732e<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a6f66b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"4a6f66b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>Yan, Yubo et al. \u201cGeneration of a human iPSC line CIBi007-A from a patient with young-onset Parkinson&#8217;s disease carrying variants in PRKN and HTRA2.\u201d Stem cell research, vol. 47 101905. 3 Jul. 2020, doi:10.1016\/j.scr.2020.101905<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u9996\u9875 \u5e15\u91d1\u68ee\u75c7\uff08Parkinson\u2019s disease\uff09\u662f\u4e00\u79cd\u5e38\u89c1\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u4e3b\u8981\u7279\u70b9\u4e3a\u9759\u6b62\u6027\u9707\u98a4\u3001\u8fd0\u52a8 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":4375,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4397","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/4397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cib.cc\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4397"}],"version-history":[{"count":6,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/4397\/revisions"}],"predecessor-version":[{"id":8543,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/4397\/revisions\/8543"}],"up":[{"embeddable":true,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/4375"}],"wp:attachment":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}