{"id":4626,"date":"2025-02-19T23:45:11","date_gmt":"2025-02-19T15:45:11","guid":{"rendered":"https:\/\/www.cib.cc\/?page_id=4626"},"modified":"2025-09-17T10:38:50","modified_gmt":"2025-09-17T02:38:50","slug":"%e5%ae%b6%e6%97%8f%e6%80%a7%e9%ab%98%e8%83%86%e5%9b%ba%e9%86%87%e8%a1%80%e7%97%87%e6%a8%a1%e5%9e%8b","status":"publish","type":"page","link":"https:\/\/www.cib.cc\/?page_id=4626","title":{"rendered":"\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u6a21\u578b"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4626\" class=\"elementor elementor-4626\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4865314 e-flex e-con-boxed e-con e-parent\" data-id=\"4865314\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d8d14bf e-con-full e-flex e-con e-child\" data-id=\"d8d14bf\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d72a7ac elementor-widget elementor-widget-hfe-breadcrumbs-widget\" data-id=\"d72a7ac\" data-element_type=\"widget\" data-widget_type=\"hfe-breadcrumbs-widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"hfe-breadcrumbs hfe-breadcrumbs-show-home\"><li class=\"hfe-breadcrumbs-item hfe-breadcrumbs-first\"><span class=\"hfe-breadcrumbs-home-icon\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-home\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M280.37 148.26L96 300.11V464a16 16 0 0 0 16 16l112.06-.29a16 16 0 0 0 15.92-16V368a16 16 0 0 1 16-16h64a16 16 0 0 1 16 16v95.64a16 16 0 0 0 16 16.05L464 480a16 16 0 0 0 16-16V300L295.67 148.26a12.19 12.19 0 0 0-15.3 0zM571.6 251.47L488 182.56V44.05a12 12 0 0 0-12-12h-56a12 12 0 0 0-12 12v72.61L318.47 43a48 48 0 0 0-61 0L4.34 251.47a12 12 0 0 0-1.6 16.9l25.5 31A12 12 0 0 0 45.15 301l235.22-193.74a12.19 12.19 0 0 1 15.3 0L530.9 301a12 12 0 0 0 16.9-1.6l25.5-31a12 12 0 0 0-1.7-16.93z\"><\/path><\/svg><\/span><a href=\"https:\/\/www.cib.cc\"><span class=\"hfe-breadcrumbs-text\">\u9996\u9875<\/span><\/a><\/li><\/ul>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b1765c0 e-flex e-con-boxed e-con e-child\" data-id=\"b1765c0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0cbfe39 elementor-widget__width-initial fix-side elementor-widget elementor-widget-shortcode\" data-id=\"0cbfe39\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5658\" class=\"elementor elementor-5658\">\n\t\t\t\t<div class=\"elementor-element elementor-element-34b33e9 e-flex e-con-boxed e-con e-parent\" data-id=\"34b33e9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f08a7c elementor-widget elementor-widget-html\" data-id=\"6f08a7c\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<script>\ndocument.addEventListener(\"DOMContentLoaded\", function() {\n    var currentUrl = window.location.href; \/\/ \u83b7\u53d6\u5f53\u524d\u9875\u9762\u7684\u8def\u5f84\n    var navLinks = document.querySelectorAll('.cib-side-bar a'); \/\/ \u83b7\u53d6\u6240\u6709\u5bfc\u822a\u94fe\u63a5\n    navLinks.forEach(function(link) {\n        if (link.href === currentUrl) { \/\/ \u5982\u679c\u94fe\u63a5\u7684href\u5305\u542b\u5f53\u524d\u8def\u5f84\n            \/\/link.style.backgroundColor = 'white'; \/\/ \u8bbe\u7f6e\u80cc\u666f\u8272\u4e3a\u767d\u8272\n            link.style.color = '#004C97';\n            var parent = link.parentElement;\n            parent.style.backgroundColor = 'white';\n        } \n    });\n});\n<\/script>\n\n<style>\n    .cib-side-bar {\n        text-indent: 20px; \/* \u589e\u52a0\u6587\u672c\u7f29\u8fdb *\/\n    }\n    #cib-side-bar-hd, #cib-side-bar-ad, #cib-side-bar-pd, #cib-side-bar-lqt, #cib-side-bar-fh {\n    text-indent: 40px; \/* \u589e\u52a0\u6587\u672c\u7f29\u8fdb *\/\n    }\n    .cib-side-bar a{\n        color:#38454A;\n    }\n    .cib-side-bar a:hover{\n        font-weight:bold;\n        color:#004397;\n<\/style>\n\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9e84b25 e-con-full e-flex e-con e-child\" data-id=\"9e84b25\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a0c99f1 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"a0c99f1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4344\">iPSCell<sup>\u24c7<\/sup>\u5165\u95e8\u7248 iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46cb84f elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"46cb84f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4348\">iPSCell<sup>\u24c7<\/sup>\u5206\u5316\u9a8c\u8bc1 iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc3ffeb elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"bc3ffeb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4369\">iPSCell<sup>\u24c7<\/sup>\u62a5\u544a\u57fa\u56e0 iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec461c2 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"ec461c2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4375\">iPSCell<sup>\u24c7<\/sup>\u75be\u75c5\u6a21\u578b iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc0263d elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"bc0263d\" data-element_type=\"widget\" id=\"cib-side-bar-pd\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4397\">\u5e15\u91d1\u68ee\u75c7<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb1657d elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"bb1657d\" data-element_type=\"widget\" id=\"cib-side-bar-ad\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4627\">\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-53e6ef3 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"53e6ef3\" data-element_type=\"widget\" id=\"cib-side-bar-lqt\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4628\">\u9057\u4f20\u6027\u957f QT \u7efc\u5408\u75c7<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57302ad elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"57302ad\" data-element_type=\"widget\" id=\"cib-side-bar-fh\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4626\">\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a9afe9 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"4a9afe9\" data-element_type=\"widget\" id=\"cib-side-bar-hd\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4629\">\u809d\u8c46\u72b6\u6838\u53d8\u6027<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cc02cc8 e-con-full e-flex e-con e-child\" data-id=\"cc02cc8\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-4ce302b e-con-full e-flex e-con e-child\" data-id=\"4ce302b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-38058b7 elementor-widget elementor-widget-heading\" data-id=\"38058b7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u6a21\u578b\uff08Familial hypercholesterolemia\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50036a4 elementor-widget__width-inherit cib-ta-con elementor-widget elementor-widget-shortcode\" data-id=\"50036a4\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n<table id=\"tablepress-68\" class=\"tablepress tablepress-id-68\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">\u8d27\u53f7<\/th><th class=\"column-2\">\u57fa\u56e0\u4fe1\u606f<\/th><th class=\"column-3\">\u7ec4\u7ec7\u6765\u6e90<\/th><th class=\"column-4\">\u91cd\u7f16\u7a0b\u5de5\u5177<\/th><th class=\"column-5\">\u4f9b\u4f53\u4eba\u79cd<\/th><th class=\"column-6\">\u4f9b\u4f53\u5e74\u9f84<\/th><th class=\"column-7\">\u4f9b\u4f53\u6027\u522b<\/th><th class=\"column-8\">\u89c4\u683c<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">iPSD0050<\/td><td class=\"column-2\">LDLR: 1241T>G; APOB: 1618 G>T<\/td><td class=\"column-3\">PBMC<\/td><td class=\"column-4\">Sendai virus<\/td><td class=\"column-5\">Asian<\/td><td class=\"column-6\">32<\/td><td class=\"column-7\">\u7537<\/td><td class=\"column-8\">\uff5e1E6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-68 from cache --><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9a96f6 elementor-widget__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"d9a96f6\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"700\" height=\"435\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/02\/fh1.png\" class=\"attachment-full size-full wp-image-4637\" alt=\"\" \/><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7cb6bde elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7cb6bde\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71f4d7a elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"71f4d7a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7(Familial hypercholesterolemia,FH)\u662f\u4e00\u79cd\u4e25\u91cd\u7684\u5e38\u67d3\u8272\u4f53\u663e\u6027\u5355\u57fa\u56e0\u9057\u4f20\u6027\u75be\u75c5\u3002\u5168\u7403\u6027\u7684 FH \u6742\u5408\u60a3\u8005\u7684\u53d1\u75c5\u7387\u7ea6\u4e3a 1\/500\uff0c\u7eaf\u5408\u5b50\u60a3\u8005\u53d1\u75c5\u7387\u7ea6\u4e3a 1\/100 \u4e07\uff0c\u662f\u8102\u8d28\u4ee3\u8c22\u5355\u57fa\u56e0\u75be\u75c5\u4e2d\u6700\u5e38\u89c1\u4e14\u6700\u4e25\u91cd\u7684\u4e00\u79cd\u3002<\/p><p>\u8be5\u75c5\u4e3b\u8981\u662f\u7531\u4e8e\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u53d7\u4f53(Low-density lipoprotein receptor, LDLR)\u57fa\u56e0\u7a81\u53d8\u800c\u5f15\u8d77\u7684\uff0c\u5728\u4e34\u5e8a\u786e\u8bca\u7684FH \u60a3\u8005\u4e2d\u7ea6 50%\u53ef\u68c0\u6d4b\u5230 LDLR \u57fa\u56e0\u7a81\u53d8\u3002\u76ee\u524d\u4e3a\u6b62\uff0c\u82f1\u56fd FH \u7684 LDLR \u7a81\u53d8\u6570\u636e\u5e93 (http:\/\/ www.ucl.ac.uk\/ ldlr\/LOVDv.1.1.0\/)\u62a5\u9053\u4e16\u754c\u8303\u56f4\u5185\u7684 LDLR \u57fa\u56e0\u7a81\u53d8\u5df2\u7ecf\u8fbe\u5230 1700 \u591a\u79cd\uff0c\u4e2d\u56fd\u4e5f\u62a5\u9053\u8fc7\u8d85\u8fc7 100 \u79cd LDLR \u57fa\u56e0\u7a81\u53d8\u7c7b\u578b\u3002FH \u60a3\u8005 LDLR \u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u7ec6\u80de\u819c\u8868\u9762 LDLR \u51cf\u5c11\u6216\u7f3a\u5931\uff0c\u673a\u4f53\u4ee3\u8c22\u80c6\u56fa\u9187\u80fd\u529b\u964d\u4f4e\uff0c\u8840\u6d46\u603b\u80c6\u56fa\u9187\u548c\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d-\u80c6\u56fa\u9187(LDL-C)\u6c34\u5e73\u5927\u5e45\u5347\u9ad8\uff0c\u8fc7\u91cf\u7684 LDL-C \u6c89\u79ef\u4e8e\u541e\u566c\u7ec6\u80de\u548c\u5176\u4ed6\u7ec6\u80de\u5185\uff0c\u5f62\u6210\u9ec4\u8272\u7624\u548c\u7ca5\u6837\u6591\u5757\uff0c\u6700\u7ec8\u5bfc\u81f4\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u53d1\u751f\u3002<\/p><p>\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\uff0c\u6211\u4eec\u5efa\u7acb\u4e86LDLR+\/-\u3001LDLR-\/- \u548cFH\u75c5\u4eba\u6765\u6e90\u7684 iPSC\u3002\u4f53\u5916\u5b9e\u9a8c\u8bc1\u5b9e\u5206\u5316\u800c\u6765\u7684\u809d\u7ec6\u80de LDL \u5438\u6536\u529f\u80fd\u53d7\u635f\uff08\u4e0b\u56fe1\uff09\u3002\u6211\u4eec\u901a\u8fc7\u6d4b\u5b9a\u57f9\u517b\u57fa\u4e2d\u7684\u603b\u80c6\u56fa\u9187\uff08TC\uff09\u548c APOB \u6c34\u5e73\uff0c\u53ef\u4ee5\u76d1\u6d4b\u809d\u7ec6\u80de\u5bf9 LDL \u7684\u5438\u6536\u80fd\u529b\uff0c\u6211\u4eec\u53d1\u73b0\u4ed6\u6c40\u53ef\u4ee5\u63d0\u5347\u4e0a\u8ff0\u809d\u7ec6\u80de\u5bf9 LDL \u7684\u5438\u6536\u80fd\u529b\uff08\u4e0b\u56fe2\uff09\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-15d3a23 e-con-full e-flex e-con e-child\" data-id=\"15d3a23\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-fb8ac93 e-con-full e-flex e-con e-child\" data-id=\"fb8ac93\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ce5e424 elementor-widget-mobile__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"ce5e424\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"950\" height=\"806\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/02\/fh2.png\" class=\"attachment-full size-full wp-image-4638\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">\u56fe1. iPSC \u6765\u6e90\u7684\u809d\u7ec6\u80de\u5bf9 LDL \u7684\u5438\u6536\u80fd\u529b<sup>1<sup><\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-657ca0a elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget-tablet__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"657ca0a\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"1065\" height=\"385\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/02\/fh3.png\" class=\"attachment-full size-full wp-image-4639\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">\u56fe2. \u5728 iPSC \u6765\u6e90\u7684\u809d\u7ec6\u80deFH\u75be\u75c5\u6a21\u578b\u4e2d\uff0c\u4ed6\u6c40\u53ef\u4ee5\u63d0\u5347\u809d\u7ec6\u80de\u5bf9 LDL \u7684\u5438\u6536\u80fd\u529b<sup>1<sup><\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9332d67 elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget-tablet__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"9332d67\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"982\" height=\"1388\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/02\/fh4.png\" class=\"attachment-full size-full wp-image-4640\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">\u56fe3. \u643a\u5e26 LDLR \u53ca APOB \u7a81\u53d8\u7684 iPSC<sup>2<sup><\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-201ef3a e-con-full e-flex e-con e-child\" data-id=\"201ef3a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4c1eadf elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4c1eadf\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c84424 elementor-widget elementor-widget-heading\" data-id=\"4c84424\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u53c2\u8003\u6587\u732e<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d64645 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"2d64645\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>Yang J.,*,Wang Y.,* et al. Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells, Stem Cell Reports, 2017, 8(3): 605~618<\/li><li>Ge W*, Song Y*, et al. Generation of a human iPSC line CIBi009-A from a patient with familial hypercholesterolemia carrying variants of LDLR c.T1241G and APOB c.G1618T. Stem Cell Research. 53 (2021) 102347.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u9996\u9875 \u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7\u6a21\u578b\uff08Familial hypercholesterolemia\uff09 \u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":4375,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4626","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/4626","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cib.cc\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4626"}],"version-history":[{"count":0,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/4626\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/4375"}],"wp:attachment":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4626"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}