{"id":4627,"date":"2025-02-20T00:18:13","date_gmt":"2025-02-19T16:18:13","guid":{"rendered":"https:\/\/www.cib.cc\/?page_id=4627"},"modified":"2025-06-10T10:44:31","modified_gmt":"2025-06-10T02:44:31","slug":"%e9%98%bf%e5%b0%94%e5%85%b9%e6%b5%b7%e9%bb%98%e7%97%87%e6%a8%a1%e5%9e%8b","status":"publish","type":"page","link":"https:\/\/www.cib.cc\/?page_id=4627","title":{"rendered":"\u963f\u5179\u6d77\u9ed8\u75c7\u6a21\u578b"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4627\" class=\"elementor elementor-4627\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4865314 e-flex e-con-boxed e-con e-parent\" data-id=\"4865314\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a226904 e-con-full e-flex e-con e-child\" data-id=\"a226904\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a178f3b elementor-widget elementor-widget-hfe-breadcrumbs-widget\" data-id=\"a178f3b\" data-element_type=\"widget\" data-widget_type=\"hfe-breadcrumbs-widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"hfe-breadcrumbs hfe-breadcrumbs-show-home\"><li class=\"hfe-breadcrumbs-item hfe-breadcrumbs-first\"><span class=\"hfe-breadcrumbs-home-icon\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-home\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M280.37 148.26L96 300.11V464a16 16 0 0 0 16 16l112.06-.29a16 16 0 0 0 15.92-16V368a16 16 0 0 1 16-16h64a16 16 0 0 1 16 16v95.64a16 16 0 0 0 16 16.05L464 480a16 16 0 0 0 16-16V300L295.67 148.26a12.19 12.19 0 0 0-15.3 0zM571.6 251.47L488 182.56V44.05a12 12 0 0 0-12-12h-56a12 12 0 0 0-12 12v72.61L318.47 43a48 48 0 0 0-61 0L4.34 251.47a12 12 0 0 0-1.6 16.9l25.5 31A12 12 0 0 0 45.15 301l235.22-193.74a12.19 12.19 0 0 1 15.3 0L530.9 301a12 12 0 0 0 16.9-1.6l25.5-31a12 12 0 0 0-1.7-16.93z\"><\/path><\/svg><\/span><a href=\"https:\/\/www.cib.cc\"><span class=\"hfe-breadcrumbs-text\">\u9996\u9875<\/span><\/a><\/li><\/ul>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b1765c0 e-flex e-con-boxed e-con e-child\" data-id=\"b1765c0\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4b9d141 elementor-widget__width-initial fix-side elementor-widget elementor-widget-shortcode\" data-id=\"4b9d141\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5658\" class=\"elementor elementor-5658\">\n\t\t\t\t<div class=\"elementor-element elementor-element-34b33e9 e-flex e-con-boxed e-con e-parent\" data-id=\"34b33e9\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6f08a7c elementor-widget elementor-widget-html\" data-id=\"6f08a7c\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<script>\ndocument.addEventListener(\"DOMContentLoaded\", function() {\n    var currentUrl = window.location.href; \/\/ \u83b7\u53d6\u5f53\u524d\u9875\u9762\u7684\u8def\u5f84\n    var navLinks = document.querySelectorAll('.cib-side-bar a'); \/\/ \u83b7\u53d6\u6240\u6709\u5bfc\u822a\u94fe\u63a5\n    navLinks.forEach(function(link) {\n        if (link.href === currentUrl) { \/\/ \u5982\u679c\u94fe\u63a5\u7684href\u5305\u542b\u5f53\u524d\u8def\u5f84\n            \/\/link.style.backgroundColor = 'white'; \/\/ \u8bbe\u7f6e\u80cc\u666f\u8272\u4e3a\u767d\u8272\n            link.style.color = '#004C97';\n            var parent = link.parentElement;\n            parent.style.backgroundColor = 'white';\n        } \n    });\n});\n<\/script>\n\n<style>\n    .cib-side-bar {\n        text-indent: 20px; \/* \u589e\u52a0\u6587\u672c\u7f29\u8fdb *\/\n    }\n    #cib-side-bar-hd, #cib-side-bar-ad, #cib-side-bar-pd, #cib-side-bar-lqt, #cib-side-bar-fh {\n    text-indent: 40px; \/* \u589e\u52a0\u6587\u672c\u7f29\u8fdb *\/\n    }\n    .cib-side-bar a{\n        color:#38454A;\n    }\n    .cib-side-bar a:hover{\n        font-weight:bold;\n        color:#004397;\n<\/style>\n\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9e84b25 e-con-full e-flex e-con e-child\" data-id=\"9e84b25\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a0c99f1 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"a0c99f1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4344\">iPSCell<sup>\u24c7<\/sup>\u5165\u95e8\u7248 iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46cb84f elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"46cb84f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4348\">iPSCell<sup>\u24c7<\/sup>\u5206\u5316\u9a8c\u8bc1 iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc3ffeb elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"bc3ffeb\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4369\">iPSCell<sup>\u24c7<\/sup>\u62a5\u544a\u57fa\u56e0 iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec461c2 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"ec461c2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4375\">iPSCell<sup>\u24c7<\/sup>\u75be\u75c5\u6a21\u578b iPSC<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc0263d elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"bc0263d\" data-element_type=\"widget\" id=\"cib-side-bar-pd\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4397\">\u5e15\u91d1\u68ee\u75c7<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb1657d elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"bb1657d\" data-element_type=\"widget\" id=\"cib-side-bar-ad\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4627\">\u963f\u5c14\u5179\u6d77\u9ed8\u75c7<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-53e6ef3 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"53e6ef3\" data-element_type=\"widget\" id=\"cib-side-bar-lqt\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.cib.cc\/?page_id=4628\">\u9057\u4f20\u6027\u957f QT \u7efc\u5408\u75c7<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57302ad elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"57302ad\" data-element_type=\"widget\" id=\"cib-side-bar-fh\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4626\">\u5bb6\u65cf\u6027\u9ad8\u80c6\u56fa\u9187\u8840\u75c7<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a9afe9 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"4a9afe9\" data-element_type=\"widget\" id=\"cib-side-bar-hd\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4629\">\u809d\u8c46\u72b6\u6838\u53d8\u6027<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5450a8e e-con-full e-flex e-con e-child\" data-id=\"5450a8e\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-9b10cd0 e-con-full e-flex e-con e-child\" data-id=\"9b10cd0\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ddaac82 elementor-widget elementor-widget-heading\" data-id=\"ddaac82\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u6a21\u578b\uff08Alzheimer's disease\uff09<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-de14ff3 elementor-widget__width-inherit cib-ta-con elementor-widget elementor-widget-shortcode\" data-id=\"de14ff3\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n<table id=\"tablepress-67\" class=\"tablepress tablepress-id-67\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">\u8d27\u53f7<\/th><th class=\"column-2\">\u57fa\u56e0\u4fe1\u606f<\/th><th class=\"column-3\">\u57fa\u56e0\u578b<\/th><th class=\"column-4\">\u89c4\u683c<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">iPSM0039<\/td><td class=\"column-2\">AAVS1\u4f4d\u70b9\u6572\u5165BACE1-2A-eGFP \u8868\u8fbe\u6846<\/td><td class=\"column-3\">Heterozygous Tg-BACE1<\/td><td class=\"column-4\">\uff5e1E6<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">iPSM0043<\/td><td class=\"column-2\">\u5f15\u5165Swedish mutation<\/td><td class=\"column-3\">APPKM (670,671) NL\/- <\/td><td class=\"column-4\">\uff5e1E6<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">iPSM0046<\/td><td class=\"column-2\">AAVS1\u4f4d\u70b9\u6572\u5165PSEN1\u25b3E9 \u8868\u8fbe\u6846<\/td><td class=\"column-3\">Homozygous Tg-PSEN1\u25b3E9<\/td><td class=\"column-4\">\uff5e1E6<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">iPSM0052<\/td><td class=\"column-2\">\u5411iPSM0043 AAVS1 KI BACE1\u8868\u8fbe\u6846<\/td><td class=\"column-3\">APPsw\/-, Tg-BACE1<\/td><td class=\"column-4\">\uff5e1E6<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">iPSM0053<\/td><td class=\"column-2\">\u5411iPSM0043 AAVS1 KI PSEN1\u25b3E9\u8868\u8fbe\u6846<\/td><td class=\"column-3\">APPsw\/-, Tg-PSEN1\u25b3E9<\/td><td class=\"column-4\">\uff5e1E6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-67 from cache --><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-931a052 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"931a052\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fc26821 e-con-full e-flex e-con e-child\" data-id=\"fc26821\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61481a5 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"61481a5\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\uff08Alzheimer&#8217;s Disease, AD\uff09\u662f\u4e00\u79cd\u6162\u6027\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\uff0c\u4e3b\u8981\u8868\u73b0\u4e3a\u8fdb\u884c\u6027\u8bb0\u5fc6\u529b\u51cf\u9000\u3001\u8ba4\u77e5\u529f\u80fd\u8870\u9000\u548c\u884c\u4e3a\u5f02\u5e38\u3002\u5b83\u662f\u8001\u5e74\u4eba\u4e2d\u6700\u5e38\u89c1\u7684\u75f4\u5446\u7c7b\u578b\uff0c\u5176\u75c5\u7406\u7279\u5f81\u5305\u62ec\u03b2-\u6dc0\u7c89\u6837\u86cb\u767d\uff08A\u03b2\uff09\u6c89\u79ef\u5f62\u6210\u7684\u6dc0\u7c89\u6837\u6591\u5757\u548c tau \u86cb\u767d\u8fc7\u5ea6\u78f7\u9178\u5316\u5bfc\u81f4\u7684\u795e\u7ecf\u7ea4\u7ef4\u7f20\u7ed3\uff0c\u6700\u7ec8\u5f15\u53d1\u795e\u7ecf\u5143\u6b7b\u4ea1\u548c\u8111\u840e\u7f29\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05cd973 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"05cd973\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1350\" height=\"739\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u6dc0\u7c89\u6837\u86cb\u767d\u5047\u8bf4\u6d89\u53ca\u5230\u7684\u5173\u952e\u57fa\u56e0.png\" class=\"attachment-full size-full wp-image-7123\" alt=\"\" \/><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">\u6dc0\u7c89\u6837\u86cb\u767d\u5047\u8bf4\u6d89\u53ca\u5230\u7684\u5173\u952e\u57fa\u56e0<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9fd588c elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"9fd588c\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A\u03b2 \u7531\u6dc0\u7c89\u6837\u524d\u4f53\u86cb\u767d\uff08APP\uff09\u7ecf BACE1 \u9176\u5207\u52a0\u5de5\u751f\u6210\u3002\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0cAPP \u901a\u8fc7 \u03b1- \u5206\u6ccc\u9176\u548c \u03b3- \u5206\u6ccc\u9176\u5207\u5272\uff0c\u4ea7\u751f\u65e0\u5bb3\u7684\u53ef\u6eb6\u6027\u7247\u6bb5\uff08\u5982sAPP\u03b1\uff09\u3002\u5728\u5f02\u5e38\u60c5\u51b5\u4e0b\uff0cAPP \u88ab \u03b2- \u5206\u6ccc\u9176\uff08BACE1\uff09\u548cPSEN1 (\u03b3-\u5206\u6ccc\u9176\u7ec4\u5206\uff09)\u4f9d\u6b21\u5207\u5272\uff0c\u751f\u6210 A\u03b2 \u5355\u4f53A\u03b240 \u548c A\u03b242\uff08\u5c24\u5176\u662f\u6bd2\u6027\u8f83\u5f3a\u7684 A\u03b242 \u4e9a\u578b\uff09\u3002A\u03b2 \u5355\u4f53\u901a\u8fc7\u758f\u6c34\u4f5c\u7528\u805a\u96c6\u6210\u5be1\u805a\u4f53\uff0c\u8fdb\u4e00\u6b65\u5f62\u6210\u7ea4\u7ef4\u72b6\u7ed3\u6784\uff0c\u6700\u7ec8\u6c89\u79ef\u4e3a\u7ec6\u80de\u5916\u7684\u6dc0\u7c89\u6837\u6591\u5757\u3002\u53ef\u6eb6\u6027A\u03b2\u5be1\u805a\u4f53\uff08\u800c\u975e\u6210\u719f\u6591\u5757\uff09\u88ab\u8ba4\u4e3a\u662f\u4e3b\u8981\u6bd2\u6027\u5f62\u5f0f\uff0c\u7834\u574f\u7a81\u89e6\u529f\u80fd\u5e76\u5f15\u53d1\u708e\u75c7\u53cd\u5e94\u3002A\u03b2 \u79ef\u7d2f\u53ef\u80fd\u4fc3\u8fdb tau \u86cb\u767d\u8fc7\u5ea6\u78f7\u9178\u5316\uff0c\u5f62\u6210\u795e\u7ecf\u7ea4\u7ef4\u7f20\u7ed3\uff0c\u8fdb\u4e00\u6b65\u7834\u574f\u7ec6\u80de\u9aa8\u67b6\u3002\u5bb6\u65cf\u6027 AD \u60a3\u8005\u4e2d\uff0cAPP \u57fa\u56e0\u7a81\u53d8\uff08\u5982swedish mutation\uff09\u6216\u65e9\u8001\u7d20\uff08PSEN1\uff09\u4f1a\u5bfc\u81f4 A\u03b242 \u8fc7\u91cf\u4ea7\u751f\u3002\u8f6c\u57fa\u56e0\u52a8\u7269\u6a21\u578b\uff08\u5982\u8fc7\u8868\u8fbe\u7a81\u53d8APP\u7684\u5c0f\u9f20\uff09\u53ef\u6a21\u62df\u6dc0\u7c89\u6837\u6591\u5757\u548c\u8ba4\u77e5\u7f3a\u9677\u30023D \u7684\u57fa\u56e0\u7f16\u8f91\u7ec6\u80de\u6a21\u578b\u53ef\u4ee5\u6a21\u62df\u5b9a\u7eb7\u6837\u677f\u5757\u548ctau\u86cb\u767d\u8fc7\u5ea6\u78f7\u9178\u5316\u5bfc\u81f4\u7684\u795e\u7ecf\u7ea4\u7ef4\u7f20\u7ed3\uff0c\u4e5f\u662f\u7814\u7a76 AD \u7684\u91cd\u8981\u6a21\u578b\u3002\u672c\u7cfb\u5217 iPSC \u901a\u8fc7\u8fc7\u8868\u8fbe \u03b2- \u5206\u6ccc\u9176\uff08BACE1\uff09\uff08IPSM0039\uff09,\u8fc7\u8868\u8fbe\u65e9\u8001\u7d20\u7a81\u53d8\u4f53\uff08PSEN1 \u0394E9\uff09\u548c\u5f15\u5165APP Swedish mutation \u6765\u6a21\u62df A\u03b2 \u5355\u4f53\u8fc7\u91cf\u751f\u6210\u548c A\u03b242 \u8fc7\u91cf\u751f\u6210\u3002\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u7684\u7ec4\u5408\u5982 iPSM0053\/ iPSM0052 \u52a0\u5feb\u4f53\u5916 AD \u8868\u578b\u7684\u8fdb\u5c55\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4ca312c e-con-full e-flex e-con e-child\" data-id=\"4ca312c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4837660 elementor-widget elementor-widget-heading\" data-id=\"4837660\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u4ea7\u54c1\u8be6\u60c5<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d56fb69 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"d56fb69\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1277db9 e-con-full e-flex e-con e-child\" data-id=\"1277db9\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4c10ca2 elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"4c10ca2\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>1. iPSM0039\uff08Tg-BACE1\uff09<\/strong><\/p><p>\u5b9a\u70b9\u6572\u5165 BACE1 \u8868\u8fbe\u6846\u5230\u4eba iPSC\uff08iPSN0051\uff09AAVS1 \u4f4d\u70b9\uff0c\u8fc7\u8868\u8fbe BACE1 \u53ef\u663e\u8457\u63d0\u5347\u57f9\u517b\u4e0a\u6e05\u4e2d A\u03b242 \u6c34\u5e73\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38d6e8c elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"38d6e8c\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"1429\" height=\"782\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u56feX3AD\u57fa\u56e0\u7f16\u8f91.png\" class=\"attachment-full size-full wp-image-7124\" alt=\"\" \/><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-230e9ea elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"230e9ea\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" width=\"2012\" height=\"550\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u56feX4.png\" class=\"attachment-full size-full wp-image-7125\" alt=\"\" \/><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cf7599a e-con-full e-flex e-con e-child\" data-id=\"cf7599a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e5d6241 elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"e5d6241\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>2. iPSM0043 \uff08APP<sup>sw\/-<\/sup>\uff09<\/strong><\/p><p>\u901a\u8fc7 ssODN \u5411 iPSN0003 \u5f15\u5165 APP Swedish mutation\uff08K670_M671delinsNL\uff09\uff0c\u540c\u65f6\u53e6\u5916\u4e00\u4e2a\u7b49\u4f4d\u57fa\u56e0\u4ea7\u751f\u79fb\u7801\u7a81\u53d8\u3002iPSM0043 \u5206\u5316\u800c\u6765\u7684\u795e\u7ecf\u5143\u57f9\u517b\u4e0a\u6e05\u4e2d A\u03b242\/ A\u03b240 \u6bd4\u503c\u660e\u663e\u63d0\u5347\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cc86efc elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"cc86efc\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"1432\" height=\"583\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u56feX6.png\" class=\"attachment-full size-full wp-image-7127\" alt=\"\" \/><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fef301a e-con-full e-flex e-con e-child\" data-id=\"fef301a\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a815573 elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"a815573\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>3. iPSM0046\uff08Tg-PSEN1\u25b3E9\uff09<\/strong><\/p><p>\u901a\u8fc7\u4f9b\u4f53\u8d28\u7c92\u5411 iPSN0003 AAVS1\u4f4d\u70b9\u5b9a\u70b9\u6572\u5165 PSEN1\u25b3E9 \u8868\u8fbe\u6846\uff0c\u63d0\u5347 iPSC \u5206\u5316\u800c\u6765\u7684\u795e\u7ecf\u5143\u57f9\u517b\u4e0a\u6e05\u4e2d A\u03b242\/ A\u03b240 \u6bd4\u503c\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cf94993 elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"cf94993\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"1407\" height=\"621\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u56feX5.png\" class=\"attachment-full size-full wp-image-7126\" alt=\"\" \/><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f8b3573 e-con-full e-flex e-con e-child\" data-id=\"f8b3573\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a130992 elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"a130992\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>4. iPSM0052\uff08APP<sup>sw\/-<\/sup>\/Tg-BACE1\uff09<\/strong><\/p><p>\u901a\u8fc7\u4f9b\u4f53\u8d28\u7c92\u5411 iPSM0043 AAVS1 \u4f4d\u70b9\u5b9a\u70b9\u6574\u5408 BACE1 \u8868\u8fbe\u6846\uff0c\u6240\u5f97 iPSC \u5206\u5316\u800c\u6765\u7684\u795e\u7ecf\u5143\u57f9\u517b\u4e0a\u6e05\u4e2dA\u03b242\/ A\u03b240 \u6bd4\u503c\u660e\u663e\u4e0a\u5347\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb71a96 elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"eb71a96\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"1168\" height=\"528\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u56feX7.png\" class=\"attachment-full size-full wp-image-7128\" alt=\"\" \/><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ff5b38 e-con-full e-flex e-con e-child\" data-id=\"8ff5b38\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-546d106 elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"546d106\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>5. iPSM0053\uff08APP<sup>sw\/-<\/sup>\/Tg-PSEN1\u25b3E9\uff09<\/strong><\/p><p>\u901a\u8fc7\u4f9b\u4f53\u8d28\u7c92\u5411 iPSM0043 AAVS1 \u4f4d\u70b9\u5b9a\u70b9\u6574\u5408 PSEN1\u25b3E9 \u8868\u8fbe\u6846\uff0c\u6240\u5f97 iPSC \u5206\u5316\u800c\u6765\u7684\u795e\u7ecf\u5143\u57f9\u517b\u4e0a\u6e05\u4e2d A\u03b242\/ A\u03b240 \u6bd4\u503c\u660e\u663e\u4e0a\u5347\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a7abfef elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"a7abfef\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"1261\" height=\"515\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u56feX8.png\" class=\"attachment-full size-full wp-image-7129\" alt=\"\" \/><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ad463d8 e-con-full e-flex e-con e-child\" data-id=\"ad463d8\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ab46b53 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ab46b53\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31324e6 elementor-widget elementor-widget-heading\" data-id=\"31324e6\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u836f\u7b5b\u6570\u636e<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b0135e5 e-con-full e-flex e-con e-child\" data-id=\"b0135e5\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-030fb70 elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"030fb70\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>1. \u7ec6\u80de\uff1aiPSM0039 neurons <\/strong><\/p><p>\u5c0f\u5206\u5b50\u836f\u7269\u5bf9AD\u6a21\u578b\uff08 BACE1\u8fc7\u8868\u8fbe\u9020\u6a21\uff09\u795e\u7ecf\u5143\u7684\u6539\u5584\uff0c<br \/>\u56fe\u4e2d\u6240\u793a CIB-m4 C1\u3001CIB-m8 C1\u3001CIB-m16 C1\u548cC2\u3001CIB-m19 C1\u548cC2\u3001CIB-m22 C1\u3001CIB-m24 C1 \u53ef\u663e\u8457\u964d\u4f4e\u7ec6\u80de\u4ea7\u751f\u7684 Abeta-42\uff0c\u5176\u4e2dCIB-m16 C2\u3001CIB-m19 C1\u3001CIB-m24 C1\u5bf9 Abeta-42\/Abeta-40 \u7684\u6bd4\u503c\u6709\u660e\u663e\u964d\u4f4e\u4f5c\u7528<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b23c7e0 elementor-widget__width-initial elementor-widget-tablet__width-inherit elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"b23c7e0\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img loading=\"lazy\" decoding=\"async\" width=\"1088\" height=\"921\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u7ec6\u80de\uff1aiPSM0039-neurons.png\" class=\"attachment-full size-full wp-image-8118\" alt=\"\" srcset=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u7ec6\u80de\uff1aiPSM0039-neurons.png 1088w, https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u7ec6\u80de\uff1aiPSM0039-neurons-300x254.png 300w, https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u7ec6\u80de\uff1aiPSM0039-neurons-1024x867.png 1024w, https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u7ec6\u80de\uff1aiPSM0039-neurons-768x650.png 768w\" sizes=\"(max-width: 1088px) 100vw, 1088px\" \/><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u9996\u9875 \u963f\u5c14\u5179\u6d77\u9ed8\u75c7\u6a21\u578b\uff08Alzheimer&#8217;s disease\uff09 \u963f\u5c14\u8328\u6d77\u9ed8\u75c7\uff08Alzheimer 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