{"id":7167,"date":"2025-03-07T17:32:39","date_gmt":"2025-03-07T09:32:39","guid":{"rendered":"https:\/\/www.cib.cc\/?page_id=7167"},"modified":"2025-03-14T09:05:14","modified_gmt":"2025-03-14T01:05:14","slug":"car-ink-%e7%bb%86%e8%83%9e","status":"publish","type":"page","link":"https:\/\/www.cib.cc\/?page_id=7167","title":{"rendered":"CAR-iNK \u7ec6\u80de"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"7167\" class=\"elementor elementor-7167\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e35f6ff e-flex e-con-boxed e-con e-parent\" data-id=\"e35f6ff\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4736da8 elementor-widget elementor-widget-hfe-breadcrumbs-widget\" data-id=\"4736da8\" data-element_type=\"widget\" data-widget_type=\"hfe-breadcrumbs-widget.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"hfe-breadcrumbs hfe-breadcrumbs-show-home\"><li class=\"hfe-breadcrumbs-item hfe-breadcrumbs-first\"><span class=\"hfe-breadcrumbs-home-icon\"><svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-home\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M280.37 148.26L96 300.11V464a16 16 0 0 0 16 16l112.06-.29a16 16 0 0 0 15.92-16V368a16 16 0 0 1 16-16h64a16 16 0 0 1 16 16v95.64a16 16 0 0 0 16 16.05L464 480a16 16 0 0 0 16-16V300L295.67 148.26a12.19 12.19 0 0 0-15.3 0zM571.6 251.47L488 182.56V44.05a12 12 0 0 0-12-12h-56a12 12 0 0 0-12 12v72.61L318.47 43a48 48 0 0 0-61 0L4.34 251.47a12 12 0 0 0-1.6 16.9l25.5 31A12 12 0 0 0 45.15 301l235.22-193.74a12.19 12.19 0 0 1 15.3 0L530.9 301a12 12 0 0 0 16.9-1.6l25.5-31a12 12 0 0 0-1.7-16.93z\"><\/path><\/svg><\/span><a href=\"https:\/\/www.cib.cc\"><span class=\"hfe-breadcrumbs-text\">\u9996\u9875<\/span><\/a><\/li><\/ul>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aac7585 e-con-full e-flex e-con e-child\" data-id=\"aac7585\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0809143 elementor-widget__width-initial fix-side elementor-widget elementor-widget-shortcode\" data-id=\"0809143\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7929\" class=\"elementor elementor-7929\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8874a54 e-flex e-con-boxed e-con e-child\" data-id=\"8874a54\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-32e3614 elementor-widget elementor-widget-html\" data-id=\"32e3614\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<script>\ndocument.addEventListener(\"DOMContentLoaded\", function() {\n    var currentUrl = window.location.href; \/\/ \u83b7\u53d6\u5f53\u524d\u9875\u9762\u7684\u8def\u5f84\n    var navLinks = document.querySelectorAll('.cib-side-bar a'); \/\/ \u83b7\u53d6\u6240\u6709\u5bfc\u822a\u94fe\u63a5\n    navLinks.forEach(function(link) {\n        if (link.href === currentUrl) { \/\/ \u5982\u679c\u94fe\u63a5\u7684href\u5305\u542b\u5f53\u524d\u8def\u5f84\n            \/\/link.style.backgroundColor = 'white'; \/\/ \u8bbe\u7f6e\u80cc\u666f\u8272\u4e3a\u767d\u8272\n            link.style.color = '#004C97';\n            var parent = link.parentElement;\n            parent.style.backgroundColor = 'white';\n\n        } \n    });\n});\n<\/script>\n\n<style>\n    .cib-side-bar {\n        text-indent: 20px; \/* \u589e\u52a0\u6587\u672c\u7f29\u8fdb *\/\n    }\n    .cib-side-bar a{\n        color:#38454A;\n    }\n    .cib-side-bar a:hover{\n        font-weight:bold;\n        color:#004397;\n    }\n<\/style>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ef89c6 e-con-full e-flex e-con e-child\" data-id=\"8ef89c6\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef926ea elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"ef926ea\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=4601\">iHSC\u7ec6\u80de<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c327174 elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"c327174\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=7169\">iNK\u7ec6\u80de<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f30437b elementor-widget__width-inherit cib-side-bar elementor-widget elementor-widget-text-editor\" data-id=\"f30437b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cib.cc\/?page_id=7167\">CAR-iNK\u7ec6\u80de<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9d4dfad e-con-full e-flex e-con e-child\" data-id=\"9d4dfad\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-5d46a5c e-con-full e-flex e-con e-child\" data-id=\"5d46a5c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6137ae8 elementor-widget elementor-widget-heading\" data-id=\"6137ae8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">CAR-iNK \u7ec6\u80de<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5d285f elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"c5d285f\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fc5168b elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"fc5168b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\u5c3d\u7ba1iNK\u5bf9\u67d0\u4e9b\u80bf\u7624\u8868\u73b0\u51fa\u5f88\u597d\u7684\u6740\u4f24\u6d3b\u6027\uff0c\u4f46\u662f\u5176\u4ecd\u4f1a\u5bf9\u90e8\u5206\u80bf\u7624\u4e0d\u654f\u611f\u3002\u8868\u8fbe\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\u5206\u5b50\u53ef\u4ee5\u63d0\u5347iNK\u6297\u539f\u4f9d\u8d56\u7684\u6740\u4f24\u80fd\u529b\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-71a2538 e-con-full e-flex e-con e-child\" data-id=\"71a2538\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e5ab38c cib-ta-con elementor-widget elementor-widget-shortcode\" data-id=\"e5ab38c\" data-element_type=\"widget\" data-widget_type=\"shortcode.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-shortcode\">\n<table id=\"tablepress-23\" class=\"tablepress tablepress-id-23 tbody-has-connected-cells\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\">\u8d27\u53f7<\/th><th class=\"column-2\">\u4ea7\u54c1\u540d\u79f0<\/th><th class=\"column-3\">\u8fc7\u8868\u8fbe\u5916\u6e90\u57fa\u56e0<br>\u6216\u6572\u9664\u5185\u6e90\u57fa\u56e0<\/th><th class=\"column-4\">\u89c4\u683c<\/th><th class=\"column-5\">\u5e94\u7528\u573a\u666f<\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">iNK003<\/td><td class=\"column-2\">anti-CD19 CAR-iNK<\/td><td class=\"column-3\">anti-CD19 CAR<\/td><td rowspan=\"10\" class=\"column-4\">\u4e0d\u5c11\u4e8e2E7\/vial\uff0c\u53ef\u6839<br>\u636e\u9700\u6c42\u5b9a\u5236\u81f35E10<\/td><td class=\"column-5\">\u6dcb\u5df4\u7624\u3001\u81ea\u514d\u75be\u75c5\u4f53\u5916\u9a8c\u8bc1<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">iNK004<\/td><td class=\"column-2\">anti-BCMA CAR-iNK<\/td><td class=\"column-3\">anti-BCMA CAR<\/td><td class=\"column-5\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4f53\u5916\u836f\u6548\u9a8c\u8bc1<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">iNK005<\/td><td class=\"column-2\">anti-GPRC5D CAR-iNK<\/td><td class=\"column-3\">anti-GPRC5D CAR<\/td><td class=\"column-5\"><\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">iNK006<\/td><td class=\"column-2\">anti-HER2 CAR-iNK<\/td><td class=\"column-3\">anti-HER2 CAR<\/td><td class=\"column-5\">HER2+\u5b9e\u4f53\u7624\u4f53\u5916\u836f\u6548\u9a8c\u8bc1<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">iNK007<\/td><td class=\"column-2\">anti-Trop2 CAR-iNK<\/td><td class=\"column-3\">anti-TROP2 CAR<\/td><td class=\"column-5\">TROP2+\u5b9e\u4f53\u7624\u4f53\u5916\u836f\u6548\u9a8c\u8bc1<\/td>\n<\/tr>\n<tr class=\"row-7\">\n\t<td class=\"column-1\">iNK008<\/td><td class=\"column-2\">anti-CD19 CAR-sIL15-iNK<\/td><td class=\"column-3\">anti-CD19 CAR\u548c\u5206\u6ccc\u578bIL15<\/td><td class=\"column-5\">\u6dcb\u5df4\u7624\u3001\u81ea\u514d\u75be\u75c5\u4f53\u5185\u836f\u4ee3\u53ca\u836f\u6548\u9a8c\u8bc1<br>\uff08IIT\u6216\u52a8\u7269\u8bd5\u9a8c\uff09<\/td>\n<\/tr>\n<tr class=\"row-8\">\n\t<td class=\"column-1\">iNK009<\/td><td class=\"column-2\">anti-BCMA CAR-sIL15-iNK<\/td><td class=\"column-3\">anti-BCMA CAR\u548c\u5206\u6ccc\u578bIL15<\/td><td class=\"column-5\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4f53\u5185\u836f\u4ee3\u53ca\u836f\u6548\u836f\u6548\u836f\u6548\u9a8c\u8bc1<br>\uff08IIT\u6216\u52a8\u7269\u8bd5\u9a8c\uff09<\/td>\n<\/tr>\n<tr class=\"row-9\">\n\t<td class=\"column-1\">iNK010<\/td><td class=\"column-2\">anti-GPRC5D CAR-sIL15-iNK<\/td><td class=\"column-3\">anti-GPRC5D CAR\u548c\u5206\u6ccc\u578bIL15<\/td><td class=\"column-5\">\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u4f53\u5185\u836f\u4ee3\u53ca\u836f\u6548\u836f\u6548\u836f\u6548\u9a8c\u8bc1<br>\uff08IIT\u6216\u52a8\u7269\u8bd5\u9a8c\uff09<\/td>\n<\/tr>\n<tr class=\"row-10\">\n\t<td class=\"column-1\">iNK011<\/td><td class=\"column-2\">anti-HER2 CAR-sIL15-iNK<\/td><td class=\"column-3\">anti-HER2 CAR\u548c\u5206\u6ccc\u578bIL15<\/td><td class=\"column-5\">HER2+\u5b9e\u4f53\u7624\u4f53\u5185\u836f\u4ee3\u53ca\u836f\u6548\u836f\u6548\u836f\u6548\u9a8c\u8bc1<br>\uff08IIT\u6216\u52a8\u7269\u8bd5\u9a8c\uff09<\/td>\n<\/tr>\n<tr class=\"row-11\">\n\t<td class=\"column-1\">iNK012<\/td><td class=\"column-2\">anti-TROP2 CAR-sIL15-iNK<\/td><td class=\"column-3\">anti-TROP2 CAR\u548c\u5206\u6ccc\u578bIL15<\/td><td class=\"column-5\">TROP2+\u5b9e\u4f53\u7624\u4f53\u5185\u836f\u4ee3\u53ca\u836f\u6548\u836f\u6548\u836f\u6548\u9a8c\u8bc1<br>\uff08IIT\u6216\u52a8\u7269\u8bd5\u9a8c\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a0dc199 e-con-full e-flex e-con e-child\" data-id=\"a0dc199\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9afd314 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"9afd314\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fbbf438 elementor-widget elementor-widget-heading\" data-id=\"fbbf438\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u9776\u70b9\u4fe1\u606f<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5556ea6 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"5556ea6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>CD19<\/strong><\/p><ul><li>B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08B-ALL\uff09: CD19 \u5728 B \u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684 B \u7ec6\u80de\u524d\u4f53\u8868\u9762\u9ad8\u8868\u8fbe\uff0c\u9488\u5bf9 CD19 \u7684 CAR-T \u7ec6\u80de\u7597\u6cd5\u5728 B-ALL \u6cbb\u7597\u4e2d\u53d6\u5f97\u4e86\u663e\u8457\u7684\u7597\u6548\uff0c\u4f8b\u5982Yescarta\u548cTecartus\u7b49CD19 CAR-T \u4ea7\u54c1\uff0c\u5df2\u88ab\u6279\u51c6\u7528\u4e8e\u6cbb\u7597B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u3002<\/li><li>B \u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff08B-NHL\uff09: CD19 \u5728\u591a\u79cd B \u7ec6\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u4e9a\u578b\u4e2d\u5747\u6709\u8868\u8fbe\uff0c\u5305\u62ec\u5f25\u6f2b\u5927 B \u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL\uff09,CD19 CAR-T\u7ec6\u80de\u7597\u6cd5\u5728 B-NHL \u7684\u6cbb\u7597\u4e2d\u4e5f\u663e\u793a\u51fa\u8f83\u9ad8\u7684\u5b8c\u5168\u7f13\u89e3\u7387\uff08CR\uff09\u548c\u5ba2\u89c2\u7f13\u89e3\u7387\uff08BOR\uff09\uff0c\u5982\u5728 DLBCL \u60a3\u8005\u4e2d\uff0c\u6709\u7814\u7a76\u663e\u793a\u5176 CR \u7387\u53ef\u8fbe51%\u3002<\/li><li>\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\uff08CLL\uff09: CD19 \u5728\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u7684B\u7ec6\u80de\u8868\u9762\u4e5f\u6709\u8868\u8fbe\uff0cCD19 CAR-T \u7ec6\u80de\u7597\u6cd5\u5728 CLL \u6cbb\u7597\u4e2d\u4e5f\u8fdb\u884c\u4e86\u76f8\u5173\u7814\u7a76\u548c\u5e94\u7528\uff0c\u4e3a CLL \u60a3\u8005\u63d0\u4f9b\u4e86\u65b0\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/li><li>\u9664\u6b64\u4e4b\u5916\uff0cCD19 \u8fd8\u662f\u591a\u79cd B \u7ec6\u80de\u5f15\u8d77\u7684\u81ea\u514d\u75be\u75c5\u7684\u9776\u70b9\uff0c\u5982\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\uff08 systemic lupus erythematosus\uff0cSLE\uff09\u3001\u7279\u53d1\u6027\u708e\u6027\u808c\u708e\uff08idiopathic inflammatory myositis, IIM\uff09\u3001\u786c\u76ae\u75c7\uff08systemic sclerosis\uff0cSS\uff09\u7b49\u3002<\/li><\/ul><p><strong>BCMA \u548c GPRC5D<\/strong><\/p><ul><li>BCMA \u548c GPRC5D \u5747\u4e3a\u4e3a\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u7684\u9776\u70b9\uff0c\u9488\u5bf9 BCMA \u7684 CAR-T \u7ec6\u80de\u7597\u6cd5\u5728\u591a\u53d1\u6027\u9aa8\u9ad3\u7624\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u663e\u8457\u7684\u7597\u6548\uff0c\u6574\u4f53\u53cd\u5e94\u7387\uff08ORR\uff09\u53ef\u8fbe48%-100%\uff0c\u5b8c\u5168\u7f13\u89e3\u7387\uff08CR\uff09\u4e3a6%-76%\u3002GPRC5D \u5728\u6076\u6027\u9aa8\u9ad3\u6d46\u7ec6\u80de\u3001\u6bdb\u56ca\u4e2d\u8868\u8fbe\u800c\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u8868\u8fbe\u5c11\u91cf\u6216\u4e0d\u8868\u8fbe\u3002GPRC5D \u5bf9\u7ecf\u6297 BCMA \u514d\u75ab\u6cbb\u7597\u590d\u53d1\u7684\u75c5\u4eba\u6709\u6548\uff0c\u76ee\u524d\u6297GPRC5DxCD3 \u53cc\u6297\u4e0a\u5e02\uff0c\u9488\u5bf9 GPRC5D \u7684\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u663e\u793a\u51fa\u5f88\u597d\u7684\u7597\u6548\u3002<\/li><\/ul><p><strong>HER2<\/strong><\/p><ul><li>HER2 \u9633\u6027\u4e73\u817a\u764c\uff1a\u5927\u7ea620%\u7684\u4e73\u817a\u764c\u7ec6\u80de\u4f1a\u8fc7\u5ea6\u8868\u8fbe HER2 \u86cb\u767d\u3002\u8fd9\u7c7b\u4e73\u817a\u764c\u901a\u5e38\u751f\u957f\u8fc5\u901f\uff0c\u4f46\u53ef\u4ee5\u901a\u8fc7\u9776\u5411\u6cbb\u7597\u836f\u7269\u5982\u66f2\u59a5\u73e0\u5355\u6297\uff08\u8d6b\u8d5b\u6c40\uff09\u7b49\u8fdb\u884c\u6709\u6548\u6cbb\u7597\u3002<\/li><li>\u80c3\u764c HER2 \u9633\u6027\u7684\u80c3\u764c\u6216\u80c3\u98df\u7ba1\u7ed3\u5408\u90e8\u817a\u764c\uff1aHER2 \u9633\u6027\u7684\u80c3\u764c\u60a3\u8005\u53ef\u4ee5\u63a5\u53d7\u66f2\u59a5\u73e0\u5355\u6297\u7b49\u9776\u5411\u6cbb\u7597\u3002<\/li><li>\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff1a\u90e8\u5206\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u5b58\u5728 HER2 \u7a81\u53d8\u6216\u8fc7\u8868\u8fbe\uff0c\u53ef\u4f7f\u7528 HER2 \u9776\u5411\u6cbb\u7597\u3002<\/li><li>HER2 \u9633\u6027\u7684\u7ed3\u76f4\u80a0\u764c\uff1a\u5728\u4e00\u4e9b\u8f6c\u79fb\u6027\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\uff0cHER2 \u8fc7\u8868\u8fbe\uff08IHC 3+\uff09\u7684\u6bd4\u4f8b\u7ea6\u4e3a1%\u52304%\u3002<\/li><li>\u5176\u4ed6\u5b9e\u4f53\u7624\uff1a\u80c6\u7ba1\u764c\u3001\u8180\u80f1\u764c\u3001\u5bab\u9888\u764c\u3001\u5b50\u5bab\u5185\u819c\u764c\u3001\u5375\u5de2\u764c\u3001\u80f0\u817a\u764c\uff1a\u8fd9\u4e9b\u80bf\u7624\u7c7b\u578b\u4e2d\u4e5f\u89c2\u5bdf\u5230 HER2 \u8fc7\u8868\u8fbe\uff08IHC 3+\uff09\uff0c\u6bd4\u4f8b\u4ece1%\u523028%\u4e0d\u7b49\u3002<\/li><\/ul><p>\u76ee\u524d\u9776\u5411\u8be5\u9776\u70b9\u7684\u6cbb\u7597\u836f\u7269 Enhertu\uff08T-DXd\uff0cDS-8201\uff09\uff0c\u662f\u4e00\u79cd HER2 \u9776\u5411\u7684\u6297\u4f53\u836f\u7269\u5076\u8054\u7269\uff08ADC\uff09\uff0c\u5df2\u88ab\u7f8e\u56fd FDA \u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u7cfb\u7edf\u6cbb\u7597\u4e14\u65e0\u6ee1\u610f\u66ff\u4ee3\u6cbb\u7597\u65b9\u6848\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f6c\u79fb\u6027 HER2 \u9633\u6027\uff08IHC 3+\uff09\u5b9e\u4f53\u7624\u60a3\u8005\u3002<\/p><p><strong>TROP2<\/strong><\/p><ul><li>\u4e73\u817a\u764c\uff1aTROP2\u5728\u4e09\u9634\u6027\u4e73\u817a\u764c\uff08TNBC\uff09\u4e2d\u9ad8\u8868\u8fbe\uff0c\u4e14\u4e0e\u80bf\u7624\u7684\u4fb5\u88ad\u6027\u548c\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002\u5728\u4e00\u4e9b\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u4e73\u817a\u764c\u4e2d\uff0cTROP2 \u4e5f\u6709\u8f83\u9ad8\u7684\u8868\u8fbe\u3002<\/li><li>\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\uff1aTROP2 \u5728 NSCLC \u4e2d\u9ad8\u8868\u8fbe\uff0c\u4e14\u4e0e\u80bf\u7624\u7684\u8fdb\u5c55\u548c\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u9488\u5bf9 TROP2 \u7684\u6297\u4f53\u5076\u8054\u836f\u7269\uff08ADC\uff09\u5982 Dato-DXd \u5728 NSCLC \u60a3\u8005\u4e2d\u663e\u793a\u51fa\u663e\u8457\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002<\/li><li>\u80f0\u817a\u764c\uff1aTROP2 \u5728\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u4e2d\u9ad8\u8868\u8fbe\uff0c\u4e14\u4e0e\u80bf\u7624\u7684\u4fb5\u88ad\u6027\u548c\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002<\/li><li>\u80c3\u764c\uff1aTROP2 \u5728\u80c3\u764c\u3001\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u3001\u5375\u5de2\u764c\u3001\u524d\u5217\u817a\u764c\uff08\u5c24\u5176\u662f\u5728\u8f6c\u79fb\u6027\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff08mCRPC\uff09\uff09\u4e2d\u9ad8\u8868\u8fbe\uff0c\u4e14\u4e0e\u80bf\u7624\u7684\u8fdb\u5c55\u548c\u9884\u540e\u4e0d\u826f\u76f8\u5173\u3002TROP2 \u5728\u591a\u79cd\u5176\u4ed6\u5b9e\u4f53\u7624\u4e2d\u4e5f\u6709\u9ad8\u8868\u8fbe\uff0c\u5305\u62ec\u5934\u9888\u764c\u3001\u80c6\u7ba1\u764c\u3001\u8180\u80f1\u764c\u7b49\u3002<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-04d4230 e-con-full e-flex e-con e-child\" data-id=\"04d4230\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-fb17bfa e-con-full e-flex e-con e-child\" data-id=\"fb17bfa\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e4adcf3 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"e4adcf3\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"788\" height=\"434\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u56fe4.-H929\u8868\u8fbeBCMA\u548cGPRC5D.png\" class=\"attachment-large size-large wp-image-7147\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20bc056 elementor-widget elementor-widget-text-editor\" data-id=\"20bc056\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tH929\u8868\u8fbeBCMA\u548cGPRC5D\uff0c\u8868\u8fbe\u6297BCMA\u7684CAR-iNK\u5177\u6709\u548cCB-NK\u53caWT-iNK\u5177\u6709\u7c7b\u4f3c\u7684\u5e7f\u8c31\u80bf\u7624\u6740\u4f24\u80fd\u529b\uff08anti-K562 cells\uff09\uff0c\u4f46\u5bf9\u8868\u8fbeBCMA\u7684\u80bf\u7624\u5177\u6709\u663e\u8457\u63d0\u5347\u7684\u6297\u539f\u4f9d\u8d56\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0373719 e-con-full e-flex e-con e-child\" data-id=\"0373719\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-65cff30 elementor-widget elementor-widget-image\" data-id=\"65cff30\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"936\" height=\"288\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/\u56fe5.-H929\u8868\u8fbeBCMA\u548cGPRC5D-.png\" class=\"attachment-large size-large wp-image-7148\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d489f01 elementor-widget elementor-widget-text-editor\" data-id=\"d489f01\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tH929\u8868\u8fbeBCMA\u548cGPRC5D \uff0c\u8868\u8fbe\u6297GPRC5D\u7684CAR-iNK\u5177\u6709\u548cCB-NK\u53caWT-iNK\u5177\u6709\u7c7b\u4f3c\u7684\u5e7f\u8c31\u80bf\u7624\u6740\u4f24\u80fd\u529b\uff08anti-K562 cells\uff09\uff0c<br>\u4f46\u5bf9\u8868\u8fbeGPRC5D\u7684\u80bf\u7624\u5177\u6709\u663e\u8457\u63d0\u5347\u7684\u6297\u539f\u4f9d\u8d56\u7684\u6297\u80bf\u7624\u6d3b\u6027\u3002\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7124ef8 e-con-full e-flex e-con e-child\" data-id=\"7124ef8\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8a9bf00 elementor-widget elementor-widget-image\" data-id=\"8a9bf00\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/GPRC5D-\u4f53\u5185-1024x576.png\" class=\"attachment-large size-large wp-image-8308\" alt=\"\" srcset=\"https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/GPRC5D-\u4f53\u5185-1024x576.png 1024w, https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/GPRC5D-\u4f53\u5185-300x169.png 300w, https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/GPRC5D-\u4f53\u5185-768x432.png 768w, https:\/\/www.cib.cc\/wp-content\/uploads\/2025\/03\/GPRC5D-\u4f53\u5185.png 1224w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\"><\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ac7d33 elementor-widget elementor-widget-text-editor\" data-id=\"3ac7d33\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>\u5355\u6b21\u7ed9\u836f\uff0c\u7ecf\u957f\u9014\u8fd0\u8f93\u7684\u51bb\u5b58iNK<\/li><li>2 million OPM2-Luc2, IV<\/li><li>1&#215;10<sup>7<\/sup> CAR-iNK<\/li><li>\u622a\u6b62\u5230day 74\uff0cCAR-iNK\u7ec4\u67093\u53ea\u5c0f\u9f20\u5b58\u6d3b<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u9996\u9875 CAR-iNK \u7ec6\u80de \u5c3d\u7ba1iNK\u5bf9\u67d0\u4e9b\u80bf\u7624\u8868\u73b0\u51fa\u5f88\u597d\u7684\u6740\u4f24\u6d3b\u6027\uff0c\u4f46\u662f\u5176\u4ecd\u4f1a\u5bf9\u90e8\u5206\u80bf\u7624\u4e0d\u654f\u611f\u3002\u8868\u8fbe\u5d4c\u5408\u6297\u539f [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":4596,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-7167","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/7167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cib.cc\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7167"}],"version-history":[{"count":0,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/7167\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/www.cib.cc\/index.php?rest_route=\/wp\/v2\/pages\/4596"}],"wp:attachment":[{"href":"https:\/\/www.cib.cc\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}