{"id":2742,"date":"2020-09-21T00:00:00","date_gmt":"2020-09-20T16:00:00","guid":{"rendered":"https:\/\/www.cib.cc\/?p=2742"},"modified":"2020-09-21T00:00:00","modified_gmt":"2020-09-20T16:00:00","slug":"%e5%a4%9a%e4%b8%80%e4%bb%bd%e7%88%b1%e5%92%8c%e7%90%86%e8%a7%a3-%e4%b8%96%e7%95%8c%e9%98%bf%e5%b0%94%e8%8c%a8%e6%b5%b7%e9%bb%98%e6%97%a5","status":"publish","type":"post","link":"https:\/\/www.cib.cc\/?p=2742","title":{"rendered":"\u591a\u4e00\u4efd\u7231\u548c\u7406\u89e3-\u4e16\u754c\u963f\u5c14\u8328\u6d77\u9ed8\u65e5"},"content":{"rendered":"

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\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u81f4\u75c5\u673a\u5236<\/span><\/strong><\/p>\n

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\u795e\u7ecf\u6027\u7ea4\u7ef4\u7f20\u7ed3\u4e0e\u8001\u5e74\u6591\u662fAD<\/span>\u7684\u4e24\u4e2a\u57fa\u672c\u75c5\u7406\u7279\u5f813<\/sup><\/span>\u3002\u800c\u8001\u5e74\u6591\u7684\u4e3b\u8981\u6210\u5206A\u03b2<\/span>\u86cb\u767d\u662f\u7531\u03b2<\/span>\u6dc0\u7c89\u6837\u6591\u539f\u59cb\u86cb\u767d\uff08APP<\/span>\uff09\u7ecf\u8fc7\u03b2<\/span>\u5206\u6ccc\u9176\uff08\u03b2-secretase<\/span>\uff09\u3001\u03b3<\/span>\u5206\u6ccc\u9176\uff08\u03b3-secretase<\/span>\uff09\u8fde\u7eed\u5207\u5272\u6210\u7684\u5927\u5c0f\u572838-43<\/span>\u4e4b\u95f4\u7684\u5c0f\u80bd\u5f62\u6210\u76844<\/sup><\/span>\u3001<\/sup>5<\/sup><\/span>\u3002\u8f83\u957f\u4e00\u70b9\u80bd\u6bb5\u5982A\u03b242<\/span>\uff0cA\u03b243<\/span>\u666e\u904d\u88ab\u8ba4\u4e3a\u6bd4\u77ed\u4e00\u70b9A\u03b240<\/span>\u66f4\u5bb9\u6613\u805a\u5408\u5f62\u6210\u8001\u5e74\u65916<\/sup><\/span>\u3002\u5728\u4ea7\u751fA\u03b242<\/span>\u8fc7\u7a0b\u4e2d\uff0cAPP<\/span>\u9996\u5148\u88ab\u03b2-secretase 1(BACE1)<\/span>\u5207\u65ad\u5f00\u6765\u751f\u6210\u4f4d\u4e8e\u80de\u5916\u7684N<\/span>\u7aefsAPP\u03b2<\/span>\u4e0eC<\/span>\u7aef\u7684C99<\/span>\u86cb\u767d\u3002C99<\/span>\u86cb\u767d\u518d\u88ab\u03b3-secretase (PSEN1,PSEN2,NCT<\/span>\u548cAPH-1<\/span>\u56db\u4e2a\u4e9a\u57fa\u7ec4\u6210\uff09\u8fd1\u4e00\u6b65\u5207\u6210\u7247\u6bb5A\u03b242<\/span>\u6216\u8005A\u03b240<\/span>\u4e0eCTF\u03b3<\/span>\u3002A\u03b242<\/span>\u5728\u80de\u5916\u6bd4A\u03b240<\/span>\u66f4\u5bb9\u6613\u805a\u96c6\u5f62\u6210\u8001\u5e74\u65917<\/sup><\/span>\u3002\u5bb6\u65cf\u6027\u7684\u8001\u5e74\u75f4\u5446\u75c7\uff08FAD<\/span>\uff09\u4e3b\u8981\u7531APP<\/span>\u57fa\u56e0\u548cPSEN1<\/span>\uff08\u03b3-secretase <\/span>\u50ac\u5316\u4e9a\u57fa\uff09\u663e\u6027\u9057\u4f20\u4e3b\u5bfc\u3002\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u03b3-secretase<\/span>\u7684\u6291\u5236\u5242\u5728\u4e34\u5e8a\u4e0a\u5bf9AD<\/span>\u672a\u663e\u793a\u6cbb\u7597\u6548\u679c\uff0c\u6240\u4ee5PSEN1<\/span>\u9519\u4e49\u7a81\u53d8\u5207\u5272C99<\/span>\u5bfc\u81f4\u7684A\u03b242<\/span>\u4e0eA\u03b240<\/span>\u6bd4\u503c\u4e0a\u5347\u662fAD<\/span>\u7684\u4e3b\u8981\u539f\u56e08<\/sup><\/span>\u3002AD<\/span>\u7684\u53e6\u5916\u4e00\u4e2a\u81f4\u75c5\u673a\u5236NFT<\/span>\uff0c\u662fTau<\/span>\u86cb\u767d\u78f7\u9178\u5316\u540e\u4e0e\u6b63\u5e38Tau<\/span>\u86cb\u767d\u805a\u96c6\u5f62\u6210\u3002\u5173\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u5177\u4f53\u81f4\u75c5\u673a\u5236\u73b0\u5728\u8ba4\u4e0d\u6e05\u695a\uff0c\u5176\u81f4\u75c5\u673a\u5236\u5047\u8bf4\u5f88\u591a\uff0c\u5305\u62ec\u6c27\u5316\u5e94\u6fc0\u5047\u8bf4\u3001\u57fa\u56e0\u7a81\u53d8\u5047\u8bf4\u3001\u80f0\u5c9b\u7d20\u5047\u8bf4\u3001\u8840\u7ba1\u56e0\u7d20\u5047\u8bf4\u3001A\u03b2-<\/span>\u6dc0\u7c89\u6837\u80bd\u7ea7\u8054\u5047\u8bf4\u4ee5\u53caTau <\/span>\u5047\u8bf4\u7b49\u3002\u5176\u4e2d\u5927\u90e8\u5206\u5b9e\u9a8c\u6570\u636e\u90fd\u652f\u6301A\u03b2-<\/span>\u6dc0\u7c89\u6837\u80bd\u7ea7\u8054\u5047\u8bf49<\/sup><\/span>\u3001<\/sup>10<\/sup><\/span>\u3002A\u03b2-<\/span>\u6dc0\u7c89\u6837\u80bd\u7ea7\u8054\u5047\u8bf4\u8ba4\u4e3a\u4eba\u4f53\u4e2d\u5b58\u5728\u7740A\u03b2<\/span>\u751f\u6210\u548c\u964d\u89e3\u7684\u52a8\u6001\u5e73\u8861\u673a\u5236\uff0c\u800cAD<\/span>\u65e9\u671f\u60a3\u8005\u8111\u4e2dA\u03b242<\/span>\u5347\u9ad8\u805a\u96c6\u5f62\u6210\u8001\u5e74\u6591\uff0c\u5bfc\u81f4Tau<\/span>\u86cb\u767d\u78f7\u9178\u5316\u5f62\u6210NFT<\/span>\uff0c\u795e\u7ecf\u5143\u6b7b\u4ea1\u3001\u8bb0\u5fc6\u529b\u8870\u9000\u3001\u884c\u4e3a\u80fd\u529b\u4e27\u5931\u548c\u6700\u7ec8\u6b7b\u4ea1\u3002<\/span><\/p>\n

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\u56fe\u6e90\uff1a<\/span>BACE1 inhibitors: Current status and future directions in treating Alzheimer’s disease<\/span><\/p>\n


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\u7814\u7a76\u6cbb\u7597\u4ece\u672a\u505c\u6b62<\/span><\/strong><\/p>\n


<\/span><\/strong><\/p>\n

\u5728\u4e2d\u56fd\u8001\u5e74\u4fdd\u5065\u534f\u4f1a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u5206\u4f1a\uff08ADC\uff09\u3001\u4eba\u6c11\u65e5\u62a5\u793e\u300a\u5065\u5eb7\u65f6\u62a5\u300b\u5171\u540c\u53d1\u8d77\u7684\u516c\u76ca\u8c03\u7814\u7ed3\u679c\u663e\u793a\uff0c\u6bcf\u4e00\u4e2a\u6570\u5b57\u80cc\u540e\u90fd\u662f\u4e00\u4e2a\u6c89\u91cd\u7684\u5bb6\u5ead\u8d1f\u62c5\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u9632\u6cbb\u7684\u836f\u7269\u7814\u7a76\u5df2\u7ecf\u523b\u4e0d\u5bb9\u7f13\u3002<\/span><\/p>\n

\u81ea 1906 \u5e74\u9996\u6b21\u62a5\u544a 1 \u4f8b 51 \u5c81\u5973\u6027\u75c5\u4f8b\u4ee5\u6765\uff0cAD \u8f7d\u5165\u533b\u5b66\u53f2\u518c\u5df2\u8fd1 110 \u5e74\uff0c\u4f46\u8fc4\u4eca\u5c1a\u65e0\u6709\u6548\u7684\u836f\u7269\u6765\u9884\u9632\u3001\u6539\u5584\u6216\u9006\u8f6c AD \u7684\u53d1\u751f\u3002\u56e0\u6b64\u7814\u53d1\u65b0\u578b\u3001\u6709\u6548\u7684 AD \u6cbb\u7597\u836f\u7269\u6210\u4e3a\u5168\u7403\u5173\u6ce8\u7684\u70ed\u70b9\u30022019\u5e74\u6709139\u79cd\u836f\u7269\u5728\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7136\u800c\u622a\u6b62\u52302020\u5e742\u670827\u65e5\uff0c\u53ea\u6709121\u79cd\u836f\u7269\u6b63\u5728\u8fdb\u884c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u4e34\u5e8a\u5b9e\u9a8c\uff0c\u81ea2004\u5e74\u4ee5\u6765\uff0cFDA\u5df2\u7ecf16\u5e74\u6ca1\u6709\u6279\u51c6\u65b0\u836f2\u300111<\/sup>\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5bf9\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u81f4\u75c5\u673a\u7406\u7684\u7814\u7a76\u4ee5\u53ca\u6cbb\u7597\u836f\u7269\u57fa\u7840\u7814\u7a76\u4ece\u672a\u505c\u6b62\u8fc7\u3002<\/span><\/p>\n

\u4e09\u542f\u751f\u7269\u4e00\u76f4\u81f4\u529b\u4e8e\u795e\u7ecf\u4e2d\u67a2\u75be\u75c5\u7684\u7814\u7a76\uff0c\u57fa\u4e8e\u03b2\u6dc0\u7c89\u6837\u6591\u81f4\u75c5\u65b9\u5411\uff0c\u6211\u4eec\u5229\u7528\u57fa\u56e0\u7f16\u8f91\u5de5\u5177\uff0c\u5efa\u7acb\u4e86\u4eba\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u4e0e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u81f4\u75c5\u57fa\u56e0\u7684\u9ad8\u6548\u3001\u7a33\u5b9a\u7684\u65b0\u578b\u963f\u5c14\u8328\u6d77\u9ed8\u75be\u75c5\u7ec6\u80de\u6a21\u578b\uff0c\u8be5\u6a21\u578b\u901a\u8fc7\u9a8c\u8bc1\u786e\u8ba4\u53ef\u4ee5\u5728\u4f53\u5916\u9ad8\u8868\u8fbeA\u03b242\uff0c\u540c\u65f6\u6ee1\u8db3\u7a33\u5b9a\u6279\u91cf\u5316\u7ec6\u80de\u751f\u4ea7\u7684\u8981\u6c42\u3002\u6211\u4eec\u76f8\u4fe1\uff0c\u901a\u8fc7\u8fd9\u4e2a\u7ec6\u80de\u6a21\u578b\uff0c\u53ef\u4ee5\u4fbf\u6377\u5730\u7814\u7a76\u963f\u5c14\u8328\u6d77\u9ed8\u75c7\u7684\u81f4\u75c5\u673a\u7406\u548c\u5f00\u53d1\u9488\u5bf9\u8be5\u75c5\u7684\u65b0\u578b\u836f\u7269\u3002<\/span><\/p>\n

\u66f4\u591a\u5173\u4e8e\u6211\u4eec\u7684AD\/PD\u836f\u7b5b\u5e73\u53f0\u7684\u6700\u65b0\u8fdb\u5c55\u548c\u6570\u636e\uff0c\u53ef\u4ee5\u5173\u6ce8\u6211\u4eec\u57282020\u5e7410\u670812-16\u53f7\u7684ThermoFisher 5 Days of Stem Cells Virtual Event\uff1a<\/span><\/p>\n

Jiayin Yang: iPSC-based high throughput platforms for screening novel therapeutics for treatment of Alzheimer’s disease and Parkinson\u2019s disease<\/span><\/p>\n

<\/p>\n

\u6587\u4f5c\u8005\uff1a\u6c5f\u5229\u9999\uff0c\u95eb\u7389\u6ce2<\/span><\/p>\n

\u56fe\u7247\u5df2\u6807\u6ce8\u51fa\u5904\uff0c\u5982\u6709\u4fb5\u6743\u8bf7\u8054\u7cfb\u5220\u9664<\/span><\/p>\n

\u4e09\u542f\u751f\u7269\u795e\u7ecf\u7ec6\u80de\u76f8\u5173\u4ea7\u54c1<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\u8d27\u53f7#<\/span><\/td>\n\u540d\u79f0<\/span><\/td>\n<\/tr>\n
iN-300<\/span><\/td>\n\u795e\u7ecf\u5e72\u7ec6\u80de<\/span><\/td>\n<\/tr>\n
iN-301<\/span><\/td>\n\u6df7\u5408\u795e\u7ecf\u5143\u7ec6\u80de<\/span><\/td>\n<\/tr>\n
iNM-001<\/span><\/td>\n\u795e\u7ecf\u5e72\u7ec6\u80de\u6269\u589e\u57f9\u517b\u57fa<\/span><\/td>\n<\/tr>\n
iNM-002<\/span><\/td>\n\u795e\u7ecf\u5143\u4fdd\u62a4\u5242\u7b5b\u9009\u8bd5\u5242\u76d2<\/span><\/td>\n<\/tr>\n
iNM-003<\/span><\/td>\nA\u03b242\u6291\u5236\u5242\u7b5b\u9009\u8bd5\u5242\u76d2<\/span><\/td>\n<\/tr>\n
iNM-004<\/span><\/td>\n\u795e\u7ecf\u7ec6\u80de\u6bd2\u6027\u6d4b\u8bd5\u8bd5\u5242\u76d2
\uff08\u57fa\u4e8eCCK8\u68c0\u6d4b\uff0c\u5305\u62ecNPC\uff0c\u57f9\u517b\u57fa\u53ca\u9633\u6027\u5bf9\u7167\uff09<\/span><\/td>\n<\/tr>\n
iNM-005<\/span><\/td>\nReady to use 96\u5b54\u677f\u6df7\u5408\u795e\u7ecf\u5143<\/span><\/span><\/td>\n<\/tr>\n
iNM-006<\/span><\/td>\n\u795e\u7ecf\u5143\u6d3b\u6027\u6d4b\u8bd5\u8bd5\u5242\u76d2<\/span><\/td>\n<\/tr>\n
iNM-007<\/span><\/td>\n\u795e\u7ecf\u5143\u6210\u719f\u57f9\u517b\u57fa<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n


<\/span><\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/span><\/p>\n

\u30101\u3011Melissa Harris, Depression Can Deepen Over Time for Alzheimer\u2019s Caregivers. Medicine Net. 2020.9.9;<\/span><\/p>\n

\u30102\u3011Jeffrey Cummings, Garam Lee, Aaron Ritter, et, al. Alzheimer\u2019s disease drug development pipeline: 2020. [J]. Alzheimers Dement (N Y) .2020:6;<\/span><\/p>\n

\u30103\u3011Estus S, Golde TE, Kunishita T, Blades D, Lowery D, Eisen M, Usiak M, Qu XM, Tabira T, Greenberg BD and et al. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science. 1992;255:726-8.<\/span><\/p>\n

\u30104\u3011Golde TE, Estus S, Younkin LH, Selkoe DJ and Younkin SG. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science. 1992;255:728-30.<\/span><\/p>\n

\u30105\u3011Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L, Jr., Eckman C, Golde TE and Younkin SG. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science. 1994;264:1336-40.<\/span><\/p>\n

\u30106\u3011Zhang X and Song W. The role of APP and BACE1 trafficking in APP processing and amyloid-beta generation. Alzheimers Res Ther. 2013;5:46.<\/span><\/p>\n

\u30107\u3011Doody RS, Raman R, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, He F, Sun X, Thomas RG, Aisen PS, Alzheimer’s Disease Cooperative Study Steering C, Siemers E, Sethuraman G, Mohs R and Semagacestat Study G. A phase 3 trial of semagacestat for treatment of Alzheimer’s disease. N Engl J Med. 2013;369:341-50.<\/span><\/p>\n

\u30108\u3011Pike CJ, Burdick D, Walencewicz AJ, Glabe CG and Cotman CW. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci. 1993;13:1676-87.<\/span><\/p>\n

\u30109\u3011Gschwind M and Huber G. Apoptotic cell death induced by beta-amyloid 1-42 peptide is cell type dependent. J Neurochem. 1995;65:292-300.<\/span><\/p>\n

\u301010\u3011Hardy JA and Higgins GA. Alzheimer’s disease: the amyloid cascade hypothesis. Science. 1992;256:184-5.<\/span><\/p>\n

\u3010<\/span>11\u3011<\/span> Jeffrey Cummings, Garam Lee, Aaron Ritter, et, al. Alzheimer\u2019s disease drug development pipeline: 2019. [<\/span>J]<\/span>. Alzheimers Dement (N Y) .2019:5<\/span><\/p>\n

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